Toxicology International (Formerly Indian Journal of Toxicology)

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Safety Evaluation of Arsenicum Album in Acute and Sub-Acute Toxicity Studies in Rats


Affiliations
1 Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, India
2 Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata - 700035, West Bengal, India
3 Central Council for Research in Homoeopathy, New Delhi - 110023, India
     

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Arsenic album is frequently prescribed in homoeopathy for many diseases. However, its safety data is not available. Thus, the study’s purpose is to evaluate the oral toxicity of Arsenic album 6C, 30C, and 200C in rats. Arsenic album (6C, 30C, and 200C) was given at 2000 μl/kg for acute toxicity and observed for up to 14 days. For subacute toxicity, it was given for 28 days and observed for clinical signs, change in body weight and Mortality. Hematological, biochemical, organ weight and histopathological analyses were assessed. Results indicate no mortality of arsenic album in acute toxicity and LD50 is >2000 μl/kg. In the subacute toxicity study, arsenic album (200 μl/kg) did not show any significant changes in above parameters. It may be concluded that the arsenic album (6C, 30C, and 200C) is safe and produces no toxicity when administered orally for a prolonged duration at 200 μl/kg in rats.

Keywords

Complementary and Alternative Medicines, Homoeopathy, Safety, Toxicity.
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  • Safety Evaluation of Arsenicum Album in Acute and Sub-Acute Toxicity Studies in Rats

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Authors

Roshan Lal
Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, India
Mahima sharma
Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, India
Sangita Behera
Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, India
Raj Kumar Regar
Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, India
Deepika Tripathi
Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, India
G V Narasimha Kumar
Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata - 700035, West Bengal, India
Satvinder Singh
Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, India
Digvijay Verma
Central Council for Research in Homoeopathy, New Delhi - 110023, India
Pankaj Gupta
Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, India
Subhash Kaushik
Central Council for Research in Homoeopathy, New Delhi - 110023, India
Anil Khurana
Central Council for Research in Homoeopathy, New Delhi - 110023, India

Abstract


Arsenic album is frequently prescribed in homoeopathy for many diseases. However, its safety data is not available. Thus, the study’s purpose is to evaluate the oral toxicity of Arsenic album 6C, 30C, and 200C in rats. Arsenic album (6C, 30C, and 200C) was given at 2000 μl/kg for acute toxicity and observed for up to 14 days. For subacute toxicity, it was given for 28 days and observed for clinical signs, change in body weight and Mortality. Hematological, biochemical, organ weight and histopathological analyses were assessed. Results indicate no mortality of arsenic album in acute toxicity and LD50 is >2000 μl/kg. In the subacute toxicity study, arsenic album (200 μl/kg) did not show any significant changes in above parameters. It may be concluded that the arsenic album (6C, 30C, and 200C) is safe and produces no toxicity when administered orally for a prolonged duration at 200 μl/kg in rats.

Keywords


Complementary and Alternative Medicines, Homoeopathy, Safety, Toxicity.

References





DOI: https://doi.org/10.18311/ti%2F2023%2Fv30i2%2F32299