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This paper investigates the relationship, and the impact of Human Resources Information System in terms of human resources planning, staffing, development, and training, employees’ performance evaluation, and compensations on the organizational loyalty of health organizations’ employees in Makkah region, as well as explore the level of importance of these variables in the health organizations under study. The model was tested using survey data collected from (134) of (2320) Managers (Ministry of Health, 1436h, p55), deputy Managers, Heads of departments, Deputy Heads of departments, and staff. Descriptive analysis, and testing (t) show the importance of human resources information systems on the organizational loyalty of health organizations’ employees. The results showed that there is a strong relationship, and the impact of the human resources information systems on the organizational loyalty of health organizations’ employees.


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