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This research paper aimed at establishing whether there is a relationship between strategic change and performance of private universities in Nairobi County. Organizations face many changes in their life span.  Whether planned or unplanned, organizations should strive to deal with the changes in order to survive. This study mainly focused on establishing whether organizational culture, leadership styles, human resources and technology influence the performance of the private universities in Nairobi County. The study targeted the 15 fully chartered private universities in Nairobi County mainly 8 top management level employees of those universities totalling to 120. Purposive sampling technique was applied which resulted to 92 as the sample size. Both qualitative and quantitative research designs were used to obtain information from the 68 respondents. Data was analyzed whose summaries were done in form of mean scores, variances and standard deviation to present the data. The study revealed that leadership styles and technology have a significant relationship with the performance while organizational culture and human resources do not significantly affect on the performance of private universities in Nairobi County. Organizations should strengthen their capabilities in leadership skills by practising more of the transformational leadership qualities, managing, developing and motivating the human resources, integrating the organization’s culture and that of the individuals and continuously improving the technology. The research findings indicated that organizational culture and human resources have no positive effect on the performance. 


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