According to the types and characteristics of labor relations coordination mechanism in Chinese manufacturing enterprises, this paper aims at constructing an adjustment path in structural equation model of labor relations coordination mechanism for the harmonious employer-employee relationship through five dimensions which respectively is the self-discipline of the employees, the management force of enterprises, the negotiation power of trade union, the guidance force of government and the supervision power of social organizations. The paper has done empirical study of the hypothetical adjustment path and further path correction which take different manufacturing enterprises from eleven cities in Zhejiang province as the object of the research. Based on the above analysis, this paper comes up with eight adjustment paths of the labor relations coordination mechanism for the harmonious employer-employee relationship, which is constructive to improve coordinative mechanism of labor relations and construct the effectively harmonious labor relationship.