The aim of this study was to determine the factors influencing entrepreneurship orientation. The unit of analysis used in this study are traders’ pizzeria in the area in the City Pelembang-Indonesia. The results showed that business performance is influenced by factors Entrepreneurship good orientation. The method used in this research is descriptive survey with the aim know the description of the object under study and explanatory survey with the aim of knowing the characteristics of variables and variable relationship. Verification analysis using Structural Equation Modeling approach Partial Least Square (PLS-SEM) using PLS Warp software version 5.0. The results showed that businesses pizzeria in the city of Palembang has enough entrepreneurial orientation, have often made efforts to develop market-oriented, and have a good business performance. Overall, the study revealed that the performance of a good business venture enterprise business performance pizzeria in town Palembang. Orientation entrepreneurship and market found that the contribution is higher than the market orientation entrepreneurial orientation, entrepreneurial and market orientation contribute to the achievement of business performance businesses provide for mediation effect entrepreneurship and market orientation in order to improve business performance pizzeria in the city of Palembang. The findings show that a good business performance is the result of which is supported by increased market orientation and entrepreneurship.