With the end of the Cold-War, global governance has experienced momentous concerns in dealing with crime necessitated by unprecedented openness in trade, travel and communication. This has seen organized and transnational crimes become more diverse and violent, leading to an increased need in multi-agency cooperation. This paper examines the extent of organized and transnational organized crime in Kenya and their effectiveness in a multi-agency security approach. The study adopts a descriptive research design that engages 256 respondents. Findings reveal that government multi-agency security organs were ineffective in their approaches due to a range of variables including corruption and poor enforcement capacity. The study recommends that the government should redesign clear and defined guidelines to manage multi-agency security organs.