An RP-HPLC Method for the Estimation of Dexibuprofen in Pharmaceutical Tablet Dosage Form

A reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of Dexibuprofen in bulk drug and pharmaceutical dosage forms. The quantification was carried out on Waters Symmetry C18 column in isocratic mode, with mobile phase consisting of Acetonitrile and water in the ratio of 55:45%(v/v), adjusted to pH 2.5 with orthophosphoric acid. The mobile phase was pumped at a rate of 1.5mL/min and detection was carried out at 214nm and linearity was found to be in the range of 40 to 160μg/mL. The correlation co-efficient was found to be 0.9991. The % recovery values were found to be in the range of 99.0 to 102%. Validation of the proposed method has also been done.