Asian Journal of Pharmaceutical Analysis

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Determination of Azelastine in Different Samples by Poly (vinyl chloride) Based Membrane Electrode


Affiliations
1 Department of Chemistry M.M.H. College Ghaziabad, India
2 Department of Pharmacy, Mewar University ,Chittorgarh, Rajasthan – 312901, India, India
     

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The selective determination of bio-active material is very important for medical point of view. Ion-selective electrode are the device used for the selective determination of target species in solutions because these device measured activity instead of molar concentration. In this work we have tested NaTFPB as potential carrier for the selective determination of azelastine in solutions. The membrane with composition of azelastine-tetrafluorophenyl borate (AZ - TFPB): DOP: PVC of 4%: 64%: 32% (w/w) works satisfactorily in the concentration range of 1.8× 10-5 - 1.0×10-1 M, has a detection limit of 1.0 × 10-5 M and fast response time of 8 seconds. The proposed electrode can be used for a period of 3 weeks in a pH range of 2.5 - 6.0. The selectivity of membrane sensor towards target ions over some common interfering ions was calculated by MPM method.

Keywords

Azelastine, Ion-selective Electrode, PVC, Ion-pair, Sodium Tetrafluorophenyl Borate
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  • Determination of Azelastine in Different Samples by Poly (vinyl chloride) Based Membrane Electrode

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Authors

Gyanendra Singh
Department of Chemistry M.M.H. College Ghaziabad, India
Seema Rani
Department of Pharmacy, Mewar University ,Chittorgarh, Rajasthan – 312901, India, India

Abstract


The selective determination of bio-active material is very important for medical point of view. Ion-selective electrode are the device used for the selective determination of target species in solutions because these device measured activity instead of molar concentration. In this work we have tested NaTFPB as potential carrier for the selective determination of azelastine in solutions. The membrane with composition of azelastine-tetrafluorophenyl borate (AZ - TFPB): DOP: PVC of 4%: 64%: 32% (w/w) works satisfactorily in the concentration range of 1.8× 10-5 - 1.0×10-1 M, has a detection limit of 1.0 × 10-5 M and fast response time of 8 seconds. The proposed electrode can be used for a period of 3 weeks in a pH range of 2.5 - 6.0. The selectivity of membrane sensor towards target ions over some common interfering ions was calculated by MPM method.

Keywords


Azelastine, Ion-selective Electrode, PVC, Ion-pair, Sodium Tetrafluorophenyl Borate

References