Asian Journal of Pharmaceutical Analysis

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Determination of Azelastine in Different Samples by Poly (vinyl chloride) Based Membrane Electrode


Affiliations
1 Department of Chemistry M.M.H. College Ghaziabad, India
2 Department of Pharmacy, Mewar University ,Chittorgarh, Rajasthan – 312901, India, India
     

   Subscribe/Renew Journal


The selective determination of bio-active material is very important for medical point of view. Ion-selective electrode are the device used for the selective determination of target species in solutions because these device measured activity instead of molar concentration. In this work we have tested NaTFPB as potential carrier for the selective determination of azelastine in solutions. The membrane with composition of azelastine-tetrafluorophenyl borate (AZ - TFPB): DOP: PVC of 4%: 64%: 32% (w/w) works satisfactorily in the concentration range of 1.8× 10-5 - 1.0×10-1 M, has a detection limit of 1.0 × 10-5 M and fast response time of 8 seconds. The proposed electrode can be used for a period of 3 weeks in a pH range of 2.5 - 6.0. The selectivity of membrane sensor towards target ions over some common interfering ions was calculated by MPM method.

Keywords

Azelastine, Ion-selective Electrode, PVC, Ion-pair, Sodium Tetrafluorophenyl Borate
Subscription Login to verify subscription
User
Notifications
Font Size


  • http://en.wikipedia.org/wiki/Azelastine

  • Lumry W, Prenner B, Corren J, Wheeler W., Efficacy and safety of azelastine nasal spray at a dose of 1 spray per nostril twice daily. Annals of Allergy, Asthma & Immunology. 99 (3); 2007: 267–72.

  • Bielory L, Buddiga P, Bigelsen S. Ocular allergy treatment comparisons: Azelastine and olopatadine. Curr Allergy Asthma Rep. 4; 2004: 320–325.

  • Baudouin C. Detrimental effect of preservative in eye drops: Implicationsfor the treatment of glaucoma. Acta Ophthalmologica. 86; 2008: 716–726.

  • Horak F, Zieglmayer UP, Zieglmayer R. Azelastine nasal spray and desloratadine tablets in pollen-induced seasonal allergic rhinitis: a pharmacodynamic study of onset of action and efficacy. Current Medical Research and Opinion. 22 (1); 2006: 151–7.

  • Ciprandi G, Ricca V, Passalacqua G. Seasonal rhinitis and azelastine: long- or short-term treatment. The Journal of Allergy and Clinical Immunology 99 (3); 1997: 301–7.

  • Horak, F, Zieglmayer, Ursula P. Azelastine nasal spray for the treatment of allergic and nonallergic rhinitis. Expert Review of Clinical Immunology 5 (6); 2009: 659–69.

  • Friedlaender MH, Harris J, LaVallee N, Russell H, Shilstone J.Evaluation of the onset and duration of effect of azelastine eye drops (0.05%) versus placebo in patients with allergic conjunctivitis using an allergen challenge model. Ophthalmology 107 (12); 2000: 2152–7.

  • Lee JS, Lee JE, Kim N, Oum BS. Comparison of the conjunctival toxicity of topical ocular antiallergic agents. J Ocul Pharmacol Ther. 24; 2008: 557–562.

  • Lambiase A, Micera A, Bonini S. Multiple action agents and the eye: Do they really stabilize mast cells? Curr Opin Allergy Clin Immunol. 9; 2009: 454–465.

  • Casale T. The interaction of azelastine with human lung histamine H1, beta, and muscarinic receptor-binding sites. J Allergy Clin Immunol. 83; 1989: 771–776.

  • Hazama H, Nakajima T, Hisada T, Hamada E, Omata M, Kurachi Y. Effects of azelastine on membrane currents in tracheal smooth muscle cells isolated from the guinea-pig. Eur J Pharmacol. 259; 1994: 143–150.

  • Greiff L, Andersson M, Svensson C, Persson CG. Topical azelastine has a 12-hour duration of action as assessed by histamine challenge-induced exudation of alpha 2-macroglobulin into human nasal airways. Clinical and Experimental Allergy 27 (4); 1997: 438–44.

  • Lieberman P, Kaliner MA, Wheeler WJ. Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. Current Medical Research and Opinion 21 (4); 2005: 611–8.

  • Shah S, Berger W, Lumry W, La Force C, Wheeler W, Sacks H. Efficacy and safety of azelastine 0.15% nasal spray and azelastine 0.10% nasal spray in patients with seasonal allergic rhinitis. Allergy and Asthma Proceedings 30 (6); 2009: 628–33.

  • Langevin CN, Pivonka J, Wichmann JK, Kucharczyk N, Sofia RD. High performance liquid chromatographic determination of azelastine and desmethylazelastine in guinea pig plasma and lung tissue. Biomed Chromatogr. 7(1); 1993: 7-11.

  • Yoo-Sin P, Shin-Hee K, Young-Jae K, Seok-Chul Y, Min-Ho L, Shaw LM, Ju-Seop K. Determination of Azelastine in Human Plasma by Validated Liquid Chromatography Coupled to Tandom Mass Spectrometry (LC-ESI/MS/MS) for the Clinical Studies. International Journal of Biomedical Science. 68(2); 2011: 120.

  • Salama NN, Abdel-Razeq SA, Abdel Atty S, El-Kosy N. Spectrophotometric determination and thermodynamics studies of the charge transfer complexes of azelastine – HCl. Bulletin of Faculty of Pharmacy, Cairo University, 49 (1); 2011: 13 – 18.

  • Adikwu MU, Ofokansi KC. Spectrophotometric determination of moclobemide by charge-transfer complexation. Journal of Pharmaceutical and Biomedical Analysis. 16 (3); 1997: 529 – 532.

  • Abdel-Razeq SA, Salama NN, Abdel-Atty S, El-Kosy N. Thermoanalytical Study and Purity Determination of Azelastine Hydrochloride and Emedastine Difumarate. Pharmaceut Anal Acta. 3 (8); 2012: 1 – 4.

  • Sawsan A. Abdel-Razeq, Foaud MM, Salama NN, Abdel-Atty S, El-Kosy N. Voltammetric Determination of Azelastine-HCl and Emedastine Difumarate in Micellar Solution at Glassy Carbon and Carbon Paste Electrodes. University Press Centre, Pardubice, Czech Republic, 6: 2011: 289 – 305.

  • Singh S, Rani G, Singh G, Agarwal H Comparative Study of Lead(II) Selective Poly(vinyl chloride) Membrane Electrodes Based on Podand Derivatives as Ionophores. Electroanalysis. 25(2); 2013: 475 -485.

  • Singh S, Rani G. Comparative Study of Holmium (III) Selective Sensors Based on Thiacalixarene and Calixarene Derivatives as an Ionophore, Bull. Korean Chem. Soc.33 (7); 2012: 2229 – 2237.

  • Singh A, Singh S, Singh G. Comparative Study of Poly(vinyl chloride) Based Polymeric Membrane Sensors for the Determination of Erbium (III) Anal. Bioanal. Electrochem.4 (3); 2012: 296-314.

  • Singh S, Rani G. A Dyanamic Electrode for the Estimation of Praseodymium(III) using 1,5-Bis-(o-aminophenol)-3-thiapentane as an Ionophore, Acta Chim. Slov. 59(1); 2012: 169-176.

  • Maliszewska-Mazur M, Torbicz W. Application of Electrochemical Sensors in Determination of Selected Drugs. Biocybernetics and Biomedical Engineering. 26 (4); 2006: 39 – 46.

  • Al Attas AS. Construction and Analytical Application of Ion Selective Bromazepam Sensor. Int. J. Electrochem. Sci. 4: 2009: 20 – 29.

  • Aboul-Enein HY, Sun XX, Sun CJ. Ion Selective PVC Membrane Electrode for the Determination of Methacycline Hydrochloride in Pharmaceutical Formulation. Sensors 2; 2002: 424-431.

  • García MS, Ortuño JA, Albero MI, Abuherba MS. Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine Sensors 9; 2009: 4309-4322.

  • Rani S, Singh G. Novel Polymeric Membrane Sensor for the Selective Determination of Citrazine. Asian J. Research Chem. 5(10); 2012: 1210 – 1215.

  • Ganjali MR, Bahareh Vesimohammadi, Riahi S, Norouzi P. Promethazine Potentiometric Membrane Sensor for Promethazine Hydrochloride Pharmaceutical Analysis; Computational Study. Int. J. Electrochem. Sci. 4; 2009: 740 – 754.

  • Basavaiah K, Shakunthala Charan VS. Ion-pair Complexometric Determination of Cyproheptadine Hydrochloride Using Bromophenol Blue. ScienceAsia. 30; 2004: 163-170

  • Ganjali MR, Memari Z, Faridbod F, Dinarvand R, Norouzi P. Electroanalysis, 20; 2008: 2663.

  • Ganjali MR, Faridbod F, Dinarvand R, Norouzi P, Adib M. Sens. Actuator B, 120; 2006: 119.

  • Zareh MM, Raga E. Shohib RE, Abd-El-Fatha M. Effect of Surfactants on Response of Promethazine PVC-Membranes. Turk J Chem. 30; 2006: 307 – 323.

  • Faridbod F. Ganjali MR, Dinarvand R, Norouzi P, Riahi S. Schiff's Bases and Crown Ethers as Supramolecular Sensing Materials in the Construction of Potentiometric Membrane Sensors. Sensors.8; 2008: 1645-1703.

  • Sokalski T, Ceresa A, Zwickl T, Pretch E. Large Improvement of the Lower Detection Limit of Ion-Selective Polymer Membrane Electrodes, J.Am. Chem. Soc. 119; 1997: 11347 – 11348.


Abstract Views: 530

PDF Views: 4




  • Determination of Azelastine in Different Samples by Poly (vinyl chloride) Based Membrane Electrode

Abstract Views: 530  |  PDF Views: 4

Authors

Gyanendra Singh
Department of Chemistry M.M.H. College Ghaziabad, India
Seema Rani
Department of Pharmacy, Mewar University ,Chittorgarh, Rajasthan – 312901, India, India

Abstract


The selective determination of bio-active material is very important for medical point of view. Ion-selective electrode are the device used for the selective determination of target species in solutions because these device measured activity instead of molar concentration. In this work we have tested NaTFPB as potential carrier for the selective determination of azelastine in solutions. The membrane with composition of azelastine-tetrafluorophenyl borate (AZ - TFPB): DOP: PVC of 4%: 64%: 32% (w/w) works satisfactorily in the concentration range of 1.8× 10-5 - 1.0×10-1 M, has a detection limit of 1.0 × 10-5 M and fast response time of 8 seconds. The proposed electrode can be used for a period of 3 weeks in a pH range of 2.5 - 6.0. The selectivity of membrane sensor towards target ions over some common interfering ions was calculated by MPM method.

Keywords


Azelastine, Ion-selective Electrode, PVC, Ion-pair, Sodium Tetrafluorophenyl Borate

References