Asian Journal of Pharmacy and Technology

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Fabrication and Evaluation of Cefpodoxime Proxetil Niosomes


Affiliations
1 Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
2 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Ananthapuramu, Andhra Pradesh, India
     

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The authors aimed to create and characterise Cefpodoxime Proxetil (CDP) niosomes with site-specific delivery in order to minimise disruptions in gastric disintegration and absorption and achieve the desired therapeutic response. CDP niosomes were created using an Ether injection process with a variety of CDP, cholesterol, and Sorbitans concentrations (Span 40, 60 and 80). Compatibility studies with the excipients used, vesicular shape, size, entrapment efficiency, drug content, and in-vitro drug release were all performed on the fabricated niosomes. The results revealed that the primed niosomes pass and satisfy all physicochemical characterizations performed. The study concludes that CDP can be formulated as niosomes by ether injection techniques for enhanced absorption of drug.

Keywords

Niosomes, Spans, Cefpodoxime Proxetil, Cholesterol, Injection, Evaluation
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  • Fabrication and Evaluation of Cefpodoxime Proxetil Niosomes

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Authors

Bandagisa Fouziya
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
Hindustan Abdul Ahad
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Ananthapuramu, Andhra Pradesh, India
Dontha Swamy Charan
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
Jagarlamudi Sri Vidya
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
Ummadi Chandana Reddy
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
Puli Nandini Reddy
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India

Abstract


The authors aimed to create and characterise Cefpodoxime Proxetil (CDP) niosomes with site-specific delivery in order to minimise disruptions in gastric disintegration and absorption and achieve the desired therapeutic response. CDP niosomes were created using an Ether injection process with a variety of CDP, cholesterol, and Sorbitans concentrations (Span 40, 60 and 80). Compatibility studies with the excipients used, vesicular shape, size, entrapment efficiency, drug content, and in-vitro drug release were all performed on the fabricated niosomes. The results revealed that the primed niosomes pass and satisfy all physicochemical characterizations performed. The study concludes that CDP can be formulated as niosomes by ether injection techniques for enhanced absorption of drug.

Keywords


Niosomes, Spans, Cefpodoxime Proxetil, Cholesterol, Injection, Evaluation

References