Effect of Vitamin C Adjuvant Therapy on Lipid Profile in Diabetes patients with Co-Morbid Cardiovascular Disease

The study was aimed to evaluate the effect of Vitamin C adjuvant therapy significantly on lipid profile and HbA1c in diabetes patients with co-morbid cardiovascular disease.A total of 64 diabetic patients were enrolled by using a randomization procedure and assigned to control group and an intervention group.Patients in the intervention group received Vitamin C 500mg bid supplementation along with antidiabetic and antihyperlipdemic therapy as per the standard treatment protocol for a period of three months, whereas patients in the control group received only antidiabetic and antihyperlipidemic therapy for a period of three months. The mean age, BMI, duration of diabetes, of the subjects were 50.04±14.58, 27.94±4.71 and 9.93±4.83 respectively. The incidence of elevated CRP was found to be 68%. No statistically significant difference for any variable of comparison of glucose, lipid parameters and CRP was detected at baseline. There was a reduction in levels of clinical variables found after 3 months of daily use of vitamin C 500mg bid in the intervention group. Based on the results of this study concluded that Vitamin C as an adjuvant therapy produces beneficial effect in type 2 diabetes patients. Vitamin C 1g/day showed improved lipid profile which helps in cardiovascular risk mitigation.