Asian Journal of Pharmacy and Technology

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Effect of Vitamin C Adjuvant Therapy on Lipid Profile in Diabetes patients with Co-Morbid Cardiovascular Disease


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1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, India
     

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The study was aimed to evaluate the effect of Vitamin C adjuvant therapy significantly on lipid profile and HbA1c in diabetes patients with co-morbid cardiovascular disease.A total of 64 diabetic patients were enrolled by using a randomization procedure and assigned to control group and an intervention group.Patients in the intervention group received Vitamin C 500mg bid supplementation along with antidiabetic and antihyperlipdemic therapy as per the standard treatment protocol for a period of three months, whereas patients in the control group received only antidiabetic and antihyperlipidemic therapy for a period of three months. The mean age, BMI, duration of diabetes, of the subjects were 50.04±14.58, 27.94±4.71 and 9.93±4.83 respectively. The incidence of elevated CRP was found to be 68%. No statistically significant difference for any variable of comparison of glucose, lipid parameters and CRP was detected at baseline. There was a reduction in levels of clinical variables found after 3 months of daily use of vitamin C 500mg bid in the intervention group. Based on the results of this study concluded that Vitamin C as an adjuvant therapy produces beneficial effect in type 2 diabetes patients. Vitamin C 1g/day showed improved lipid profile which helps in cardiovascular risk mitigation.

Keywords

Vitamin C, Adjuvant Therapy, Antihyperlipidemic Therapy
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  • Effect of Vitamin C Adjuvant Therapy on Lipid Profile in Diabetes patients with Co-Morbid Cardiovascular Disease

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Authors

P. Geetha
Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, India
M. Varaprasannarao
Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, India
D. Subalakshmi
Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, India
R. V. Bibi Bergin
Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, India

Abstract


The study was aimed to evaluate the effect of Vitamin C adjuvant therapy significantly on lipid profile and HbA1c in diabetes patients with co-morbid cardiovascular disease.A total of 64 diabetic patients were enrolled by using a randomization procedure and assigned to control group and an intervention group.Patients in the intervention group received Vitamin C 500mg bid supplementation along with antidiabetic and antihyperlipdemic therapy as per the standard treatment protocol for a period of three months, whereas patients in the control group received only antidiabetic and antihyperlipidemic therapy for a period of three months. The mean age, BMI, duration of diabetes, of the subjects were 50.04±14.58, 27.94±4.71 and 9.93±4.83 respectively. The incidence of elevated CRP was found to be 68%. No statistically significant difference for any variable of comparison of glucose, lipid parameters and CRP was detected at baseline. There was a reduction in levels of clinical variables found after 3 months of daily use of vitamin C 500mg bid in the intervention group. Based on the results of this study concluded that Vitamin C as an adjuvant therapy produces beneficial effect in type 2 diabetes patients. Vitamin C 1g/day showed improved lipid profile which helps in cardiovascular risk mitigation.

Keywords


Vitamin C, Adjuvant Therapy, Antihyperlipidemic Therapy

References