Asian Journal of Research in Chemistry

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Pharmacological and Synthetic Profile of 1, 2, 4-Triazoles


Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS-413736, India
2 Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Nashik, M.S., India
3 Department of pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, India
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, India
     

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Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities. Triazoles can be synthesized using Einhorn-Brunner reaction or the Pellizzari reaction from acyl hydrazides. Triazoles posses wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the various developments in synthesis and biological activities of triazole derivatives.

Keywords

1, 2, 4-Triazole, Pharmacological Activity, SAR, Total Synthesis.
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  • Pharmacological and Synthetic Profile of 1, 2, 4-Triazoles

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Authors

Nachiket S. Dighe
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS-413736, India
Ravindra B. Saudagar
Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Nashik, M.S., India
Ramesh S. Kalkotwar
Department of pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, India
D. A. Jain
Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, India

Abstract


Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities. Triazoles can be synthesized using Einhorn-Brunner reaction or the Pellizzari reaction from acyl hydrazides. Triazoles posses wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the various developments in synthesis and biological activities of triazole derivatives.

Keywords


1, 2, 4-Triazole, Pharmacological Activity, SAR, Total Synthesis.