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Synthesis and Pharmacology of Some Aryloxypropanolamine Derivatives


Affiliations
1 Department of Pharmaceutical Chemistry, P.E.S.’s Modern College of Pharmacy, Nigdi, Pune – 411 044, India
2 Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Maharashtra, India
     

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4-hydroxy-3-methoxy benzaldehyde on reaction with substituted anilines gave imine compounds (2a-d) which on reaction with epichlorhydrin gave epoxides (3a-d). These compounds on reaction with amines gave 1-(2-methoxy-4-arylimino phenoxy)-3-(substituted amino)-propan-2-ol (4a-h). All newly synthesized compounds were characterized on the basis of spectral analysis and evaluated for β-blocking activity. Compound (4e) was found to be most potent compound of this series and was compared with the reference drug, propranolol. Other compounds in this series were found to possess varied degree of β-blocking activity.

Keywords

Aryloxypropanolamines, β-Blocking Activity.
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  • Synthesis and Pharmacology of Some Aryloxypropanolamine Derivatives

Abstract Views: 231  |  PDF Views: 0

Authors

S. B. Jadhav
Department of Pharmaceutical Chemistry, P.E.S.’s Modern College of Pharmacy, Nigdi, Pune – 411 044, India
P. Y. Shirodkar
Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Maharashtra, India

Abstract


4-hydroxy-3-methoxy benzaldehyde on reaction with substituted anilines gave imine compounds (2a-d) which on reaction with epichlorhydrin gave epoxides (3a-d). These compounds on reaction with amines gave 1-(2-methoxy-4-arylimino phenoxy)-3-(substituted amino)-propan-2-ol (4a-h). All newly synthesized compounds were characterized on the basis of spectral analysis and evaluated for β-blocking activity. Compound (4e) was found to be most potent compound of this series and was compared with the reference drug, propranolol. Other compounds in this series were found to possess varied degree of β-blocking activity.

Keywords


Aryloxypropanolamines, β-Blocking Activity.