Asian Journal of Research in Chemistry

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Synthesis and Antibacterial Study of Some New Schiff's Bases of 2- Hydrazinyl-1-(1H-Imidazole-1-yl)-Ethanone


Affiliations
1 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana-384001, Gujarat, India
     

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Imidazole on reaction with chloroacetyl chloride afford 2-chloro-1-(1H-imidazole-1-yl)-ethanone, 1 which on treatment with hydrazine hydrate has yielded 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone, 2. Condensation of 2 with various aromatic aldehydes afforded sustituted Schiff’s base of 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone. The structures of all the products were characterized on the basis of their IR, Mass and 1H-NMR spectroscopic data analysis. All the synthesised products were screened for their antibacterial activity against gram-positive and gram negative bacteria by cup-plate method.


Keywords

Synthesis, Imidazole, Aromatic Aldehydes, Schiff’s Bases, Antibacterial Activity.
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  • Synthesis and Antibacterial Study of Some New Schiff's Bases of 2- Hydrazinyl-1-(1H-Imidazole-1-yl)-Ethanone

Abstract Views: 251  |  PDF Views: 1

Authors

Ravi N. Patel
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana-384001, Gujarat, India
Urviben Yashodharabhai Patel
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana-384001, Gujarat, India
Ripal R. Chaudhari
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana-384001, Gujarat, India
Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana-384001, Gujarat, India

Abstract


Imidazole on reaction with chloroacetyl chloride afford 2-chloro-1-(1H-imidazole-1-yl)-ethanone, 1 which on treatment with hydrazine hydrate has yielded 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone, 2. Condensation of 2 with various aromatic aldehydes afforded sustituted Schiff’s base of 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone. The structures of all the products were characterized on the basis of their IR, Mass and 1H-NMR spectroscopic data analysis. All the synthesised products were screened for their antibacterial activity against gram-positive and gram negative bacteria by cup-plate method.


Keywords


Synthesis, Imidazole, Aromatic Aldehydes, Schiff’s Bases, Antibacterial Activity.