Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Synthesis and Cytotoxic Activity of New Indole Derivatives


Affiliations
1 Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, India
2 University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, India
     

   Subscribe/Renew Journal


Some new (Napthalen-1-yloxyl/2-yloxy)-acetic acid (2-oxo-1, 2-dihydro-indole-3-ylidene)-hydrazides (4 and 5) have been synthesized by condensing naphthyl-1-oxy/2-oxy acetic acid hydrazides with different isatins. Their chemical structures have been confirmed by IR, NMR, and Mass spectroscopy and by elemental analysis. Investigation of cytotoxic activity was done by MTT assay method using HeLa and MCF cell lines. The compounds with 6-Bromo substitution (4e, 5e) have shown the prominent cytotoxic activity among the synthesized compounds.

Keywords

Synthesis/Indoles/Cytotoxicity.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 242

PDF Views: 1




  • Synthesis and Cytotoxic Activity of New Indole Derivatives

Abstract Views: 242  |  PDF Views: 1

Authors

C. Radhika
Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, India
Venkatesham Akena
University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, India
J. Venkateshwar Rao
Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, India
M. Sarangapani
University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, India

Abstract


Some new (Napthalen-1-yloxyl/2-yloxy)-acetic acid (2-oxo-1, 2-dihydro-indole-3-ylidene)-hydrazides (4 and 5) have been synthesized by condensing naphthyl-1-oxy/2-oxy acetic acid hydrazides with different isatins. Their chemical structures have been confirmed by IR, NMR, and Mass spectroscopy and by elemental analysis. Investigation of cytotoxic activity was done by MTT assay method using HeLa and MCF cell lines. The compounds with 6-Bromo substitution (4e, 5e) have shown the prominent cytotoxic activity among the synthesized compounds.

Keywords


Synthesis/Indoles/Cytotoxicity.