Asian Journal of Research in Chemistry

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Synthesis and Characterization of Schiff Base CoII, NiII and CuII Complexes Derived from 2-Hydroxy-1-Naphthaldehyde and Ethylenediamine


Affiliations
1 Department of Chemistry, A.V.V.M Sri Pushpam College Poondi, Thanjavur, Tamilnadu, India
     

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New CoII, NiII and CuII complex has been synthesized and characterized by elemental analysis, UV-Vis, FT-IR and thermal analysis Binding of this CoII, NiII and CuII complex with calf thymus DNA was investigated by UVVisible absorption, fluorescence spectroscopy techniques. The intrinsic binding constants Kb of complex with CT-DNA obtained from UV-Vis absorption studies. Further, the in vitro cytotoxic effect of the complexes examined on cancerous cell line, such as human breast cancer cells (MCF-7).

Keywords

CoII, NiII and CuII complex, DNA Interaction, Electrochemical Studies and Cytotoxicity Activity.
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  • Synthesis and Characterization of Schiff Base CoII, NiII and CuII Complexes Derived from 2-Hydroxy-1-Naphthaldehyde and Ethylenediamine

Abstract Views: 233  |  PDF Views: 3

Authors

Kadhiravansivasamy
Department of Chemistry, A.V.V.M Sri Pushpam College Poondi, Thanjavur, Tamilnadu, India
S. Sivajiganesan
Department of Chemistry, A.V.V.M Sri Pushpam College Poondi, Thanjavur, Tamilnadu, India
T. Periyathambi
Department of Chemistry, A.V.V.M Sri Pushpam College Poondi, Thanjavur, Tamilnadu, India
V. Nandhakumar
Department of Chemistry, A.V.V.M Sri Pushpam College Poondi, Thanjavur, Tamilnadu, India
M. Pugazhenthi
Department of Chemistry, A.V.V.M Sri Pushpam College Poondi, Thanjavur, Tamilnadu, India

Abstract


New CoII, NiII and CuII complex has been synthesized and characterized by elemental analysis, UV-Vis, FT-IR and thermal analysis Binding of this CoII, NiII and CuII complex with calf thymus DNA was investigated by UVVisible absorption, fluorescence spectroscopy techniques. The intrinsic binding constants Kb of complex with CT-DNA obtained from UV-Vis absorption studies. Further, the in vitro cytotoxic effect of the complexes examined on cancerous cell line, such as human breast cancer cells (MCF-7).

Keywords


CoII, NiII and CuII complex, DNA Interaction, Electrochemical Studies and Cytotoxicity Activity.