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Synthesis and Characterization of Schiff Base CoII, NiII and CuII Complexes Derived from 2-Hydroxy-1-Naphthaldehyde and Ethylenediamine
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New CoII, NiII and CuII complex has been synthesized and characterized by elemental analysis, UV-Vis, FT-IR and thermal analysis Binding of this CoII, NiII and CuII complex with calf thymus DNA was investigated by UVVisible absorption, fluorescence spectroscopy techniques. The intrinsic binding constants Kb of complex with CT-DNA obtained from UV-Vis absorption studies. Further, the in vitro cytotoxic effect of the complexes examined on cancerous cell line, such as human breast cancer cells (MCF-7).
Keywords
CoII, NiII and CuII complex, DNA Interaction, Electrochemical Studies and Cytotoxicity Activity.
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