Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Synthesis and Evaluation of Pyrrole Derivative Conjugates of Aspirin as Anti-Platelet Agents


Affiliations
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
2 Jamiya Hamdard University, New Delhi, India
     

   Subscribe/Renew Journal


A new series of NSAID’S in which aspirin is joined by ester linkage to pyrrole-2-carboxylic acid were synthesized and tested for anti-platelet activity. Related propyl esters of aspirin and aspirin as such were taken as references. All the compounds described here show anti-platelet activity but they do not behave as prodrugs of aspirin in blood serum.

Keywords

NSAID’S, Aspirin, Anti-Platelet Agents, Pyrrole.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 192

PDF Views: 0




  • Synthesis and Evaluation of Pyrrole Derivative Conjugates of Aspirin as Anti-Platelet Agents

Abstract Views: 192  |  PDF Views: 0

Authors

Saurabh Chaturvedi
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
Rakesh Saini
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
A. N. Kesari
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
Awani Rai
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
Neelotma Maurya
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
M. Shahar Yar
Jamiya Hamdard University, New Delhi, India

Abstract


A new series of NSAID’S in which aspirin is joined by ester linkage to pyrrole-2-carboxylic acid were synthesized and tested for anti-platelet activity. Related propyl esters of aspirin and aspirin as such were taken as references. All the compounds described here show anti-platelet activity but they do not behave as prodrugs of aspirin in blood serum.

Keywords


NSAID’S, Aspirin, Anti-Platelet Agents, Pyrrole.