Asian Journal of Research in Chemistry

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Synthesis and Evaluation of Pyrrole Derivative Conjugates of Aspirin as Anti-Platelet Agents


Affiliations
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
2 Jamiya Hamdard University, New Delhi, India
     

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A new series of NSAID’S in which aspirin is joined by ester linkage to pyrrole-2-carboxylic acid were synthesized and tested for anti-platelet activity. Related propyl esters of aspirin and aspirin as such were taken as references. All the compounds described here show anti-platelet activity but they do not behave as prodrugs of aspirin in blood serum.

Keywords

NSAID’S, Aspirin, Anti-Platelet Agents, Pyrrole.
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  • Synthesis and Evaluation of Pyrrole Derivative Conjugates of Aspirin as Anti-Platelet Agents

Abstract Views: 240  |  PDF Views: 0

Authors

Saurabh Chaturvedi
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
Rakesh Saini
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
A. N. Kesari
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
Awani Rai
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
Neelotma Maurya
Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), India
M. Shahar Yar
Jamiya Hamdard University, New Delhi, India

Abstract


A new series of NSAID’S in which aspirin is joined by ester linkage to pyrrole-2-carboxylic acid were synthesized and tested for anti-platelet activity. Related propyl esters of aspirin and aspirin as such were taken as references. All the compounds described here show anti-platelet activity but they do not behave as prodrugs of aspirin in blood serum.

Keywords


NSAID’S, Aspirin, Anti-Platelet Agents, Pyrrole.