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Microwave-Assisted Synthesis and Antibacterial Activity of Some New Flavones and 1, 5-Benzothiazepines
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The synthesis of heterocyclic compounds containing flavones (4a-i) and 1,5-benzothiazepines (5a-i) from chalcone derivatives containing 3,4-methylenedioxy phenyl ring using microwave irradiation in 80-97% yield within 2-4 min. The work-up is simple, shorter reaction time, increase in reaction rate with better yields. The structures of synthetic compounds have been characterized using IR and 1H NMR spectral data together with halogen analysis. All synthesized compounds have been screened for their antibacterial activity.
Keywords
Chalcones, Flavones, 1,5-Benzothiazepines, Microwave Irradiation, Antibacterial Activity.
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