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Microwave-Assisted Synthesis and Antibacterial Activity of Some New Flavones and 1, 5-Benzothiazepines


Affiliations
1 P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.), India
     

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The synthesis of heterocyclic compounds containing flavones (4a-i) and 1,5-benzothiazepines (5a-i) from chalcone derivatives containing 3,4-methylenedioxy phenyl ring using microwave irradiation in 80-97% yield within 2-4 min. The work-up is simple, shorter reaction time, increase in reaction rate with better yields. The structures of synthetic compounds have been characterized using IR and 1H NMR spectral data together with halogen analysis. All synthesized compounds have been screened for their antibacterial activity.

Keywords

Chalcones, Flavones, 1,5-Benzothiazepines, Microwave Irradiation, Antibacterial Activity.
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  • Microwave-Assisted Synthesis and Antibacterial Activity of Some New Flavones and 1, 5-Benzothiazepines

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Authors

V. A. Navale
P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.), India
S. S. Mokle
P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.), India
Archana Y. Vibhute
P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.), India
K. G. Karamunge
P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.), India
S. V. Khansole
P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.), India
S. B. Junne
P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.), India
Y. B. Vibhute
P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.), India

Abstract


The synthesis of heterocyclic compounds containing flavones (4a-i) and 1,5-benzothiazepines (5a-i) from chalcone derivatives containing 3,4-methylenedioxy phenyl ring using microwave irradiation in 80-97% yield within 2-4 min. The work-up is simple, shorter reaction time, increase in reaction rate with better yields. The structures of synthetic compounds have been characterized using IR and 1H NMR spectral data together with halogen analysis. All synthesized compounds have been screened for their antibacterial activity.

Keywords


Chalcones, Flavones, 1,5-Benzothiazepines, Microwave Irradiation, Antibacterial Activity.