Asian Journal of Research in Chemistry

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Two Wavelength Method for Estimation of Risperidone and Trihexyphenidyl HCl in Combined Tablet Dosage Form


Affiliations
1 Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
     

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No one UV Spectrophotometric method is available for simultaneous estimation of Risperidone (RIS) and Trihexyphenidyl HCL (THP). The objective of present work is to develop a new, simple, accurate and sensitive UVspectrophotometric two wavelength method for simultaneous determination of RIS and THP in combined pharmaceutical dosage form. Two wavelength i,e 238 nm and 271 nm were selected for estimation of RIS where as wavelength 217 nm was selected for estimation of THP using 0.1 N HCL solution as solvent . RIS and THP shows linearity in the concentration range of 0-40 μg/ml and 0-80 μg/ml respectively. The method was validated statistically.

Keywords

Risperidone, Trihexyphenidyl HCL, Two wavelength method
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  • Two Wavelength Method for Estimation of Risperidone and Trihexyphenidyl HCl in Combined Tablet Dosage Form

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Authors

A. B. Roge
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
G. R. Shendarkar
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
N. Y. Gond
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
N. B. Ghiware
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
S. M. Vadvalkar
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India

Abstract


No one UV Spectrophotometric method is available for simultaneous estimation of Risperidone (RIS) and Trihexyphenidyl HCL (THP). The objective of present work is to develop a new, simple, accurate and sensitive UVspectrophotometric two wavelength method for simultaneous determination of RIS and THP in combined pharmaceutical dosage form. Two wavelength i,e 238 nm and 271 nm were selected for estimation of RIS where as wavelength 217 nm was selected for estimation of THP using 0.1 N HCL solution as solvent . RIS and THP shows linearity in the concentration range of 0-40 μg/ml and 0-80 μg/ml respectively. The method was validated statistically.

Keywords


Risperidone, Trihexyphenidyl HCL, Two wavelength method

References