Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Two Wavelength Method for Estimation of Risperidone and Trihexyphenidyl HCl in Combined Tablet Dosage Form


Affiliations
1 Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
     

   Subscribe/Renew Journal


No one UV Spectrophotometric method is available for simultaneous estimation of Risperidone (RIS) and Trihexyphenidyl HCL (THP). The objective of present work is to develop a new, simple, accurate and sensitive UVspectrophotometric two wavelength method for simultaneous determination of RIS and THP in combined pharmaceutical dosage form. Two wavelength i,e 238 nm and 271 nm were selected for estimation of RIS where as wavelength 217 nm was selected for estimation of THP using 0.1 N HCL solution as solvent . RIS and THP shows linearity in the concentration range of 0-40 μg/ml and 0-80 μg/ml respectively. The method was validated statistically.

Keywords

Risperidone, Trihexyphenidyl HCL, Two wavelength method
Subscription Login to verify subscription
User
Notifications
Font Size


  • Stahl SM. Essential psychopharmacology. Cambridge: Cambridge University Press; 2000, 2nd ed.: pp.425-34.

  • Titier K, Dridet E, Cardone E, Abouelfath A, Moore N. Simplified high-performance liquid chromatographic method for determination of risperidone and 9-hydroxyrisperidone in plasma after overdose. J. Chromatogr. Biomed. Sci. Appl. 772; 2002:373-8.

  • Woestenborghs R, Lorreyne W, Rompaey F, Heykants J. Determination of risperidone and 9-hydroxyrisperidone in plasma, urine and animal tissues by high-performance liquid chromatography. J. Chromatogr. B, Biomed. Sci. Appl. 583; 1992: 223-30.

  • Titier K, Bouchet S, Phourcq F, Moore N, Molimard M. Highperformance liquid chromatographic method with diode array detection to identify and quantify atypical antipsychotics and haloperidol in plasma after overdose. J. Chromatogr. Biomed. Sci. Appl. 788; 2003:179-85.

  • Zhou Z, Li X, Li K, Xie Z, Cheng Z, Peng W. Simultaneous determination of clozapine, olanzapine, risperidone and quetiapine in plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. Biomed. Sci. Appl. 802; 2004: 257-62.

  • Flarakos J, Luo W, Aman M, Svinarov D, Gerber N, Vouros P. Quantification of risperidone and 9-hydroxyrisperidone in plasma and saliva from adult and pediatric patients by liquid chromatography-mass spectrometry. J. Chromatogr. Biomed. Sci. Appl. 1026; 2004:175-83.

  • Remmerie BM, Sips L, Vries R, Jong J, Schothuis A, Hooijschuur E. Validated method for the determination of risperidone and 9-hydroxyrisperidone in human plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. Biomed. Sci. Appl. 783; 2003: 461-72.

  • Moing J, Edouard S, Levron J. Determination of risperidone and 9-hydroxyrisperidone in human plasma by high-performance liquid chromatography with electrochemical detection. J. Chromatogr. Biomed. Sci. Appl. 614; 1993:333-9.

  • Sherif EL, Zeanu B, Houssini M. High performance liquid chromatographic and thin layer densitometric methods for the determination of risperidone in the presence of its degradation products in bulk powder and in tablets. J Pharm Biomed Anal. 36; 2005:975-81.

  • Tomar RS, Joseph TJ, Murthy AS, Yadav DV, Subbaiah G, Krishna Reddy KV. Identification and characterization of major degradation products of risperidone in bulk drug and pharmaceutical dosage forms. J Pharm Biomed Anal. 36; 2004:231-35.

  • Merck Index S., In; The Merck Index, Merck and Co., Inc., Whitehouse Station, NJ, 13th Edn, 2001: 4611, 9770.

  • British Pharmacopoeia, Vol.II, 2008.

  • United State Pharmacopoeia, Vol.III, 2009, 3804.

  • Bladania SL, Bhatt KK, Mehta RS, Shah DA. RP-HPLC estimation of risperidone in tablet dosage forms. Indian J Pharm Sci. 70; 2008:494-7.

  • Mahadik KR., Aggarwal H., Kaul N. RP-HPLC Estimation of Trihexyphenidyl HCl and Chlorpromazine HCl in Tablets. Indian Drugs. 39(8); 2002: 441-445.


Abstract Views: 422

PDF Views: 2




  • Two Wavelength Method for Estimation of Risperidone and Trihexyphenidyl HCl in Combined Tablet Dosage Form

Abstract Views: 422  |  PDF Views: 2

Authors

A. B. Roge
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
G. R. Shendarkar
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
N. Y. Gond
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
N. B. Ghiware
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India
S. M. Vadvalkar
Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, India

Abstract


No one UV Spectrophotometric method is available for simultaneous estimation of Risperidone (RIS) and Trihexyphenidyl HCL (THP). The objective of present work is to develop a new, simple, accurate and sensitive UVspectrophotometric two wavelength method for simultaneous determination of RIS and THP in combined pharmaceutical dosage form. Two wavelength i,e 238 nm and 271 nm were selected for estimation of RIS where as wavelength 217 nm was selected for estimation of THP using 0.1 N HCL solution as solvent . RIS and THP shows linearity in the concentration range of 0-40 μg/ml and 0-80 μg/ml respectively. The method was validated statistically.

Keywords


Risperidone, Trihexyphenidyl HCL, Two wavelength method

References