Asian Journal of Research in Chemistry

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Development and Validation of UV Spectrophotometric method for estimation of Ethamsylate in bulk and pharmaceutical dosage forms


Affiliations
1 A.R. College of Pharmacy and G.H. Patel Institute of Pharmacy, Vallabh Vidhyanagar, Dist: Anand, Gujarat
     

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A selective, simple, accurate and reproducible spectrophotometric method has been developed for the estimation of Ethamsylate in bulk and pharmaceutical formulation. The drug obeyed the Beer's law and showed good correlation. It showed absorption maxima at 300nm in 0.1N HCL. The developed method was validated with respect to linearity, accuracy and precision. The linearity was observed between 10-35μg/ml having line equationY=0.018x-0.0098with correlation coefficient of 0.999. Results of the analysis were validated statistically and by recovery study

Keywords

UV-Vis Spectrophotometer, Ethamsylate, Recovery, max
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  • Development and Validation of UV Spectrophotometric method for estimation of Ethamsylate in bulk and pharmaceutical dosage forms

Abstract Views: 424  |  PDF Views: 2

Authors

Priti. H. Patel
A.R. College of Pharmacy and G.H. Patel Institute of Pharmacy, Vallabh Vidhyanagar, Dist: Anand, Gujarat
Vaishali V. Kharkhanis
A.R. College of Pharmacy and G.H. Patel Institute of Pharmacy, Vallabh Vidhyanagar, Dist: Anand, Gujarat

Abstract


A selective, simple, accurate and reproducible spectrophotometric method has been developed for the estimation of Ethamsylate in bulk and pharmaceutical formulation. The drug obeyed the Beer's law and showed good correlation. It showed absorption maxima at 300nm in 0.1N HCL. The developed method was validated with respect to linearity, accuracy and precision. The linearity was observed between 10-35μg/ml having line equationY=0.018x-0.0098with correlation coefficient of 0.999. Results of the analysis were validated statistically and by recovery study

Keywords


UV-Vis Spectrophotometer, Ethamsylate, Recovery, max

References