Asian Journal of Research in Chemistry

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Synthesis, Characterization, and Antibacterial Activity of some Chelates in O,n-donor Coordination Pattern Involving Schiff Bases Derived from 4-acetyl/benzoyl-1-(4'-nitrophenyl)-3-methyl-2-pyrazolin-5-one and Sulfamoxole


Affiliations
1 School of Chemistry, University of KwaZulu-Natal, Durban, 4000
2 Department of Chemistry, Navjivan Science College, Dahod, 389 151, Gujarat, India
     

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The condensation reactions of 4-Acetyl/benzoyl-1-(4'-nitrophenyl)-3-methyl-2-pyrazolin-5-ones condensed with sulfamoxole to form bidentate NO donor Schiff bases were studied. The prepared Schiff base ligands were further utilized for the formation of metal chelates having the general formula [ML2.2H2O] where M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and L = Ligand L1 and Ligand L2. These new compounds were characterized by conductance measurements, magnetic susceptibility measurements, elemental analysis, thermo gravimetric analysis, electronic and infrared spectroscopy. Both Schiff base ligands were found to have a mono-anionic bidentate nature and octahedral geometry was assigned to all metal complexes. All the complexes contained coordinated water which was lost at 141- 160 °C. These compounds were also screened for their in-vitro antibacterial activity against three bacterial species, namely; Escherichia coli, Bacillus subtilis and Staphylococcus aureus. The metal complexes were found to have greater antibacterial activity than the Schiff base ligands

Keywords

Pyrazolin-5-one, Sulfamoxole, Schiff Base, Transition Metals, Spectroscopy, Antibacterial Activity
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  • Synthesis, Characterization, and Antibacterial Activity of some Chelates in O,n-donor Coordination Pattern Involving Schiff Bases Derived from 4-acetyl/benzoyl-1-(4'-nitrophenyl)-3-methyl-2-pyrazolin-5-one and Sulfamoxole

Abstract Views: 331  |  PDF Views: 2

Authors

A.S Thakar
School of Chemistry, University of KwaZulu-Natal, Durban, 4000
H.B Friedrich
School of Chemistry, University of KwaZulu-Natal, Durban, 4000
K.T Joshi
Department of Chemistry, Navjivan Science College, Dahod, 389 151, Gujarat, India

Abstract


The condensation reactions of 4-Acetyl/benzoyl-1-(4'-nitrophenyl)-3-methyl-2-pyrazolin-5-ones condensed with sulfamoxole to form bidentate NO donor Schiff bases were studied. The prepared Schiff base ligands were further utilized for the formation of metal chelates having the general formula [ML2.2H2O] where M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and L = Ligand L1 and Ligand L2. These new compounds were characterized by conductance measurements, magnetic susceptibility measurements, elemental analysis, thermo gravimetric analysis, electronic and infrared spectroscopy. Both Schiff base ligands were found to have a mono-anionic bidentate nature and octahedral geometry was assigned to all metal complexes. All the complexes contained coordinated water which was lost at 141- 160 °C. These compounds were also screened for their in-vitro antibacterial activity against three bacterial species, namely; Escherichia coli, Bacillus subtilis and Staphylococcus aureus. The metal complexes were found to have greater antibacterial activity than the Schiff base ligands

Keywords


Pyrazolin-5-one, Sulfamoxole, Schiff Base, Transition Metals, Spectroscopy, Antibacterial Activity

References