Asian Journal of Research in Chemistry

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Synthesis, Anti-bacterial, Anti-fungal and Anti-inflammatory Activities of some Novel 3, 5-Diaryl-1-Aryl Pyrazoline Derivatives


Affiliations
1 Research Scholar, Bhagwant University, Ajmer and Department of Pharmaceutical Chemistry, Maratha Mandal’s College of Pharmacy, Belgaum. 590 016
2 Department of Pharmaceutical Chemistry, KLE University’s, College of Pharmacy, Rajajinagar, Bangalore-40
     

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4-substituted acetanilide on treatment with substituted benzaldehyde affords the corresponding chalcones (C<SUB>13</SUB>-C<SUB>24</SUB>). Further treatment of chalcones with phenylhydrazine undergone cyclocondensation and gave a new series of novel 3, 5-Diaryl-1-aryl-2- pyrazoline (P13-P24). All synthesized compounds were screened for their antibacterial and antifungal activity at 75&#956;g concentration and anti-inflammatory activity at 200mg/ kg body weight. Some of the compounds have shown excellent activity

Keywords

Pyrazoline, Antibacterial, Antifungal, Anti-tubercular Activity
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  • Synthesis, Anti-bacterial, Anti-fungal and Anti-inflammatory Activities of some Novel 3, 5-Diaryl-1-Aryl Pyrazoline Derivatives

Abstract Views: 322  |  PDF Views: 2

Authors

M. D. Bhanushali
Research Scholar, Bhagwant University, Ajmer and Department of Pharmaceutical Chemistry, Maratha Mandal’s College of Pharmacy, Belgaum. 590 016
S. M. Hipparagi
Department of Pharmaceutical Chemistry, KLE University’s, College of Pharmacy, Rajajinagar, Bangalore-40

Abstract


4-substituted acetanilide on treatment with substituted benzaldehyde affords the corresponding chalcones (C<SUB>13</SUB>-C<SUB>24</SUB>). Further treatment of chalcones with phenylhydrazine undergone cyclocondensation and gave a new series of novel 3, 5-Diaryl-1-aryl-2- pyrazoline (P13-P24). All synthesized compounds were screened for their antibacterial and antifungal activity at 75&#956;g concentration and anti-inflammatory activity at 200mg/ kg body weight. Some of the compounds have shown excellent activity

Keywords


Pyrazoline, Antibacterial, Antifungal, Anti-tubercular Activity

References