Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Spectrophotometric Determination of Oxcarbazepine in Bulk and Pharmaceutical Formulations


Affiliations
1 Department of Chemistry, Adikavi Nannaya University, Rajahmundry,-533105, India
2 Department of Chemistry, Acharya Nagarjuna University, Guntur-521201, India
     

   Subscribe/Renew Journal


Two new rapid, simple, sensitive reproducible and economical spectrophotometric methods are described for the determination of Oxcarbazepine (OXC) in bulk form. Both methods are based on the formation of colored complexes due to the action of 4-Amino phenazone and IsoNiconitic Hydrazide on OXC in alcoholic medium. Under optimized conditions, they show an absorption maxima at 440nm (4-AP) and 450nm (INH), with molar absorptivities of 3.824 x10<SUP>4</SUP> and 2.838x10<SUP>4</SUP> mole- cm- and sand ells sensitivities of 0.08474 and 0.13968 per 0.001 absorbance unit for 4-AP and INH, respectively. The color is stable for 5 min after extraction. In both cases Beers law is obeyed between 2.5- 12.5 &#181;g/ ml. The proposed method was successfully extended to bulk and Pharmaceutical dosage forms.

Keywords

Oxcarbazepine (OXC) 4-amino phenazone (4-AP), Isonicotinic hydrazide (INH), Spectrophotometry, Condensation
Subscription Login to verify subscription
User
Notifications
Font Size



  • Spectrophotometric Determination of Oxcarbazepine in Bulk and Pharmaceutical Formulations

Abstract Views: 411  |  PDF Views: 2

Authors

Muralikrishna
Department of Chemistry, Adikavi Nannaya University, Rajahmundry,-533105, India
C. Rambabu
Department of Chemistry, Acharya Nagarjuna University, Guntur-521201, India

Abstract


Two new rapid, simple, sensitive reproducible and economical spectrophotometric methods are described for the determination of Oxcarbazepine (OXC) in bulk form. Both methods are based on the formation of colored complexes due to the action of 4-Amino phenazone and IsoNiconitic Hydrazide on OXC in alcoholic medium. Under optimized conditions, they show an absorption maxima at 440nm (4-AP) and 450nm (INH), with molar absorptivities of 3.824 x10<SUP>4</SUP> and 2.838x10<SUP>4</SUP> mole- cm- and sand ells sensitivities of 0.08474 and 0.13968 per 0.001 absorbance unit for 4-AP and INH, respectively. The color is stable for 5 min after extraction. In both cases Beers law is obeyed between 2.5- 12.5 &#181;g/ ml. The proposed method was successfully extended to bulk and Pharmaceutical dosage forms.

Keywords


Oxcarbazepine (OXC) 4-amino phenazone (4-AP), Isonicotinic hydrazide (INH), Spectrophotometry, Condensation

References