Asian Journal of Research in Chemistry

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Simultaneous Estimation of Cinitapride Hydrogen Tartrate (CNT) and Pantoprazole Sodium Sesquihydrate (PNP) in Capsule by Q-analysis UV- Spectrophotometric Method


Affiliations
1 Adv. V. R. Manohar Institute of Diploma in Pharmacy, Wanadongri, Hingna Road, Nagpur–441110, India
2 Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University, Nagpur, India
     

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Cinitapride and Pantoprazole are available as capsule dosage forms in the ratio 1:13.33. A simple reproducible and efficient method for the simultaneous determination of cinitapride and pantoprazole in marketed formulation was developed. The proposed method is based on the Q-analysis UV-Spectrophotometric method. The absorbance maximum of cinitapride and pantoprazole were found to be 265.5 nm and 268 nm respectively in water. In Q-analysis, the isoabsorptive point for both the drugs was found at 236 nm. The linearity range lies between 5-30 μg/ml for cinitapride and pantoprazole at their respective wavelengths. Both the drugs obey Beers law. The recovery studies confirmed the accuracy of the proposed method.

Keywords

Pantoprazole, Cinitapride, Q-analysis, Simultaneous Estimation
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  • Simultaneous Estimation of Cinitapride Hydrogen Tartrate (CNT) and Pantoprazole Sodium Sesquihydrate (PNP) in Capsule by Q-analysis UV- Spectrophotometric Method

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Authors

M. D. Shende
Adv. V. R. Manohar Institute of Diploma in Pharmacy, Wanadongri, Hingna Road, Nagpur–441110, India
N. R. Dighade
Adv. V. R. Manohar Institute of Diploma in Pharmacy, Wanadongri, Hingna Road, Nagpur–441110, India
A. V. Kasture
Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University, Nagpur, India

Abstract


Cinitapride and Pantoprazole are available as capsule dosage forms in the ratio 1:13.33. A simple reproducible and efficient method for the simultaneous determination of cinitapride and pantoprazole in marketed formulation was developed. The proposed method is based on the Q-analysis UV-Spectrophotometric method. The absorbance maximum of cinitapride and pantoprazole were found to be 265.5 nm and 268 nm respectively in water. In Q-analysis, the isoabsorptive point for both the drugs was found at 236 nm. The linearity range lies between 5-30 μg/ml for cinitapride and pantoprazole at their respective wavelengths. Both the drugs obey Beers law. The recovery studies confirmed the accuracy of the proposed method.

Keywords


Pantoprazole, Cinitapride, Q-analysis, Simultaneous Estimation

References