Asian Journal of Research in Pharmaceutical Sciences

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Development of Solid Self Nanoemulsifying Drug Delivery System of Quercetin


Affiliations
1 College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram, Kerala 695011,, India
     

   Subscribe/Renew Journal


This work aims to develop Solid Self Emulsifying Drug Delivery System of Quercetin for enhancing its bioavailability. From the perspective of dosage forms, Solid Self Emulsifying Drug Delivery System mean solid dosage forms with self-emulsification properties. Liquid Self Emulsifying Drug Delivery System containing 15 mg/ml of Quercetin was prepared and converted to Solid Self Emulsifying Drug Delivery System by adsorption onto various solid carriers. Based on micromeritic properties and drug content analysis Aerosil ® 200 was selected as the adsorbent for development of Solid Self Emulsifying Drug Delivery System of Quercetin.Various formulation were prepared by variying amounts of the components and optimized fornulation showed particle size of 264.2 nm and drug content of 93.95 %.Optimized Solid Self Emulsifying Drug Delivery System of Quercetin showed good self emulsification ,absence of interactions(FTIR analyis), solubilization of the drug in the mixture (DSC and XRD analysis)and smooth surface (SEM analysis ) . In-vitro drug release of Solid Self Emulsifying Drug Delivery System of Quercetin revealed percentage drug release of 99.70±0.227% within 30 min . Results of the study indicates the Solid Self emulsification technique is a promising approach for development of stable dosage form of drugs with poor oral absorption.

Keywords

Quercetin, Solid self-nanoemulsifying drug delivery system, micromeritic properties, In vitro evaluation, solid adsorption technique, bioavailability
Subscription Login to verify subscription
User
Notifications
Font Size


  • Lennernäs H, Abrahamsson B, Persson EM, Knutson L. Oral drug absorption and the biopharmaceutics classification system. Journal of Drug Delivery Science and Technology. 2007 Jan 1;17(4):237-44. doi.:10.1016/s1773-2247(07)50090-0

  • Rodriguez-Aller M, Guillarme D, Veuthey JL, Gurny R. Strategies for formulating and delivering poorly water-soluble drugs. Journal of Drug Delivery Science and Technology. 2015 Dec 1;30:342-51. doi:10.1016/j.jddst.2015.05.009

  • Pouton CW. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. European Journal of Pharmaceutical Sciences. 2006 Nov 1;29(3-4):278-87.doi:10.1016/j.ejps.2006.04.016

  • Singh SR, Jadhav KR, Tripathi PK. Design and Characterization of Self Emulsifying Drug Delivery System of Simvastatin: A Technical Note. Research Journal of Pharmacy and Technology. 2019;12(7):3397-404. doi.:10.5958/0974-360x.2019.00574.2

  • Pagar KR, Darekar AB. Nanoemulsion: A new concept of Delivery System. Asian Journal of Research in Pharmaceutical Science. 2019;9(1):39-46. doi:10.5958/2231-5659.2019.00006.7

  • Bhargavi P, Naha A, Kannan S, Rama A. Development, evaluation and optimization of solid self emulsifying drug delivery system (s-sedds) of lercanidipine hydrochloride. Research Journal of Pharmacy and Technology. 2020;13(10):4931-40. doi.org:10.5958/0974-360x.2020.00866.5

  • Thennarasu A. Quercetin in health and disease. Research Journal of Pharmacy and Technology. 2013;6(12):1397-9.

  • Almeida SR, Tippavajhala VK. A rundown through various methods used in the formulation of solid self-emulsifying drug delivery systems (S-SEDDS). Aaps Pharmscitech. 2019 Nov;20(8):1-4. doi:10.1208/s12249-019-1550-5

  • Jadhav RP, Koli VW, Kamble AB, Bhutkar MA. A Review on Nanoemulsion. Asian Journal of Research in Pharmaceutical Science. 2020;10(2):103-8. doi:10.5958/2231-5659.2020.00020.x

  • Joshi M, Pathak S, Sharma S, Patravale V. Solid microemulsion preconcentrate (NanOsorb) of artemether for effective treatment of malaria. International Journal of Pharmaceutics. 2008 Oct 1;362(1-2):172-8. doi:10.1016/j.ijpharm.2008.06.012

  • Nasr A, Gardouh A, Ghorab M. Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: design, formulation, pharmacokinetic and bioavailability evaluation. Pharmaceutics. 2016 Sep;8(3):20. doi:10.3390/pharmaceutics8030020

  • Mathew R, Varkey J. Development of a Validated RP-HPLC Method for Estimation of Quercetin. Asian Journal of Pharmaceutical and Health Sciences. 2021;11(1). doi:10.5530/ajphs.2021.11.1

  • Salve PS. Optimization of variables for solid self emulsifying drug delivery system for insoluble drug. Research Journal of Pharmacy and Technology. 2011;4(10):1581-7.

  • Beg S, Sandhu PS, Batra RS, Khurana RK, Singh B. QbD-based systematic development of novel optimized solid self-nanoemulsifying drug delivery systems (SNEDDS) of lovastatin with enhanced biopharmaceutical performance. Drug Delivery. 2015 Aug 18;22(6):765-84. doi:10.3109/10717544.2014.900154

  • Jangde R, Singh D. Compatibility studies of quercetin with pharmaceutical excipients used in the development of novel formulation. Research Journal of Pharmacy and Technology. 2014;7(10):1101-5.

  • Sambandam B, Thiyagarajan DE, Ayyaswamy AR, Raman PA, Kulasekaran J, Venkatasamy H. Extraction and isolation of flavonoid quercetin from the leaves of Trigonella foenum-graecum and their anti-oxidant activity. Int J Pharm Pharm Sci. 2016;8(6):120-4.

  • Pralhad T, Rajendrakumar K. Study of freeze-dried quercetin–cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis. Journal of Pharmaceutical and Biomedical Analysis. 2004 Feb 4;34(2):333-9. doi:10.1016/s0731-7085(03)00529-6

  • Hazra M, Mandal DD, Mandal T, Bhuniya S, Ghosh M. Designing polymeric microparticulate drug delivery system for hydrophobic drug quercetin. Saudi Pharmaceutical Journal. 2015 Sep 1;23(4):429-36. doi:10.1016/j.jsps.2015.01.007

  • Inugala S, Eedara BB, Sunkavalli S, Dhurke R, Kandadi P, Jukanti R, Bandari S. Solid self-nanoemulsifying drug delivery system (S-SNEDDS) of darunavir for improved dissolution and oral bioavailability: in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences. 2015 Jul 10;74:1-0. doi:10.1016/j.ejps.2015.03.024

  • Weerapol Y, Limmatvapirat S, Nunthanid J, Sriamornsak P. Self-nanoemulsifying drug delivery system of nifedipine: impact of hydrophilic–lipophilic balance and molecular structure of mixed surfactants. AAPS Pharmscitech. 2014 Apr;15(2):456-64. doi:10.1208/s12249-014-0078-y


Abstract Views: 257

PDF Views: 0




  • Development of Solid Self Nanoemulsifying Drug Delivery System of Quercetin

Abstract Views: 257  |  PDF Views: 0

Authors

Roma Mathew
College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram, Kerala 695011,, India
Joyamma Varkey
College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram, Kerala 695011,, India

Abstract


This work aims to develop Solid Self Emulsifying Drug Delivery System of Quercetin for enhancing its bioavailability. From the perspective of dosage forms, Solid Self Emulsifying Drug Delivery System mean solid dosage forms with self-emulsification properties. Liquid Self Emulsifying Drug Delivery System containing 15 mg/ml of Quercetin was prepared and converted to Solid Self Emulsifying Drug Delivery System by adsorption onto various solid carriers. Based on micromeritic properties and drug content analysis Aerosil ® 200 was selected as the adsorbent for development of Solid Self Emulsifying Drug Delivery System of Quercetin.Various formulation were prepared by variying amounts of the components and optimized fornulation showed particle size of 264.2 nm and drug content of 93.95 %.Optimized Solid Self Emulsifying Drug Delivery System of Quercetin showed good self emulsification ,absence of interactions(FTIR analyis), solubilization of the drug in the mixture (DSC and XRD analysis)and smooth surface (SEM analysis ) . In-vitro drug release of Solid Self Emulsifying Drug Delivery System of Quercetin revealed percentage drug release of 99.70±0.227% within 30 min . Results of the study indicates the Solid Self emulsification technique is a promising approach for development of stable dosage form of drugs with poor oral absorption.

Keywords


Quercetin, Solid self-nanoemulsifying drug delivery system, micromeritic properties, In vitro evaluation, solid adsorption technique, bioavailability

References