Asian Journal of Research in Pharmaceutical Sciences

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Development of Solid Self Nanoemulsifying Drug Delivery System of Quercetin


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1 College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram, Kerala 695011,, India
     

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This work aims to develop Solid Self Emulsifying Drug Delivery System of Quercetin for enhancing its bioavailability. From the perspective of dosage forms, Solid Self Emulsifying Drug Delivery System mean solid dosage forms with self-emulsification properties. Liquid Self Emulsifying Drug Delivery System containing 15 mg/ml of Quercetin was prepared and converted to Solid Self Emulsifying Drug Delivery System by adsorption onto various solid carriers. Based on micromeritic properties and drug content analysis Aerosil ® 200 was selected as the adsorbent for development of Solid Self Emulsifying Drug Delivery System of Quercetin.Various formulation were prepared by variying amounts of the components and optimized fornulation showed particle size of 264.2 nm and drug content of 93.95 %.Optimized Solid Self Emulsifying Drug Delivery System of Quercetin showed good self emulsification ,absence of interactions(FTIR analyis), solubilization of the drug in the mixture (DSC and XRD analysis)and smooth surface (SEM analysis ) . In-vitro drug release of Solid Self Emulsifying Drug Delivery System of Quercetin revealed percentage drug release of 99.70±0.227% within 30 min . Results of the study indicates the Solid Self emulsification technique is a promising approach for development of stable dosage form of drugs with poor oral absorption.

Keywords

Quercetin, Solid self-nanoemulsifying drug delivery system, micromeritic properties, In vitro evaluation, solid adsorption technique, bioavailability
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  • Development of Solid Self Nanoemulsifying Drug Delivery System of Quercetin

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Authors

Roma Mathew
College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram, Kerala 695011,, India
Joyamma Varkey
College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram, Kerala 695011,, India

Abstract


This work aims to develop Solid Self Emulsifying Drug Delivery System of Quercetin for enhancing its bioavailability. From the perspective of dosage forms, Solid Self Emulsifying Drug Delivery System mean solid dosage forms with self-emulsification properties. Liquid Self Emulsifying Drug Delivery System containing 15 mg/ml of Quercetin was prepared and converted to Solid Self Emulsifying Drug Delivery System by adsorption onto various solid carriers. Based on micromeritic properties and drug content analysis Aerosil ® 200 was selected as the adsorbent for development of Solid Self Emulsifying Drug Delivery System of Quercetin.Various formulation were prepared by variying amounts of the components and optimized fornulation showed particle size of 264.2 nm and drug content of 93.95 %.Optimized Solid Self Emulsifying Drug Delivery System of Quercetin showed good self emulsification ,absence of interactions(FTIR analyis), solubilization of the drug in the mixture (DSC and XRD analysis)and smooth surface (SEM analysis ) . In-vitro drug release of Solid Self Emulsifying Drug Delivery System of Quercetin revealed percentage drug release of 99.70±0.227% within 30 min . Results of the study indicates the Solid Self emulsification technique is a promising approach for development of stable dosage form of drugs with poor oral absorption.

Keywords


Quercetin, Solid self-nanoemulsifying drug delivery system, micromeritic properties, In vitro evaluation, solid adsorption technique, bioavailability

References