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Ameliorative Effects of the Homeopathic Medicine Lycopodium 200c and Extract of Phyllanthus emblica in Cadmium-Induced Neurotoxicity in Mice


Affiliations
1 Genetics and Molecular Biology Unit, Department of Zoology, Vidyasagar University, Midnapore 721 102, India
2 Department of Zoology, Vidyasagar College, Kolkata 700 006, India
 

Cadmium is an extremely toxic heavy metal and causes neurotoxicity by inducing oxidative stress and membrane disturbances in brain. Phyllanthus emblica and Lycopodium 200c have anti-oxidative properties and are able to remove the cadmium-produced free radicals. This study investigates the role of Lycopodium 200c and Phyllanthus emblica (amlaki) in ameliorating the toxic effects of cadmium on the brain of mice. Swiss albino mice were used and divided into four different sets with one control, one induced, one with amlaki and other with both amlaki and Lycopodium treatment. To observe the changes, tests for brain acetylcholinesterase along with Mg2+ ATPase activities were performed. Results show that cadmium toxicity leads to decrease in enzymatic activities which can be reversed by the effects of amlaki and Lycopodium 200c.

Keywords

Antioxidative Properties, Cadmium, Free Radicals, Oxidative Stress, Toxicity.
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  • Ameliorative Effects of the Homeopathic Medicine Lycopodium 200c and Extract of Phyllanthus emblica in Cadmium-Induced Neurotoxicity in Mice

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Authors

Mahasweta Chatterjee
Genetics and Molecular Biology Unit, Department of Zoology, Vidyasagar University, Midnapore 721 102, India
Anupama De
Genetics and Molecular Biology Unit, Department of Zoology, Vidyasagar University, Midnapore 721 102, India
Gobinda Chandra Sadhukhan
Department of Zoology, Vidyasagar College, Kolkata 700 006, India
Jayanta Kumar Kundu
Genetics and Molecular Biology Unit, Department of Zoology, Vidyasagar University, Midnapore 721 102, India

Abstract


Cadmium is an extremely toxic heavy metal and causes neurotoxicity by inducing oxidative stress and membrane disturbances in brain. Phyllanthus emblica and Lycopodium 200c have anti-oxidative properties and are able to remove the cadmium-produced free radicals. This study investigates the role of Lycopodium 200c and Phyllanthus emblica (amlaki) in ameliorating the toxic effects of cadmium on the brain of mice. Swiss albino mice were used and divided into four different sets with one control, one induced, one with amlaki and other with both amlaki and Lycopodium treatment. To observe the changes, tests for brain acetylcholinesterase along with Mg2+ ATPase activities were performed. Results show that cadmium toxicity leads to decrease in enzymatic activities which can be reversed by the effects of amlaki and Lycopodium 200c.

Keywords


Antioxidative Properties, Cadmium, Free Radicals, Oxidative Stress, Toxicity.

References





DOI: https://doi.org/10.18520/cs%2Fv111%2Fi8%2F1368-1371