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Extraction and Analysis of Ketamine (a Rave Drug) from Spiked Fruit Juices Using MEPS-MS for Forensic Purposes


Affiliations
1 Department of Forensic Science, Punjabi University, Patiala 147 002, India
2 Department of Pharmaceutical Sciences and Drugs Research, Punjabi University, Patiala 147 002, India
 

Micro extraction packed sorbent (MEPS) containing C8 and SCX (strong cation exchange) is employed to extract ketamine, a rave drug from fruit juices. The eluant was detected by mass spectral analysis wherein the drug was detected as a parent as well as some prominent fragment ions. The resultant MEPS-MS method proved very efficient and rapid. The mass spectrum of the eluant showed the parent ion peak (MH+) of ketamine at m/z 238 along with (MH2+) peak (30% of MH+) due to chlorine atom in the drug molecule. The daughter ions at m/z 220 and 207 were possible to be formed from the MH+ by loss of water and methylamine molecule respectively. Another daughter ion at m/z 179 was proposed to be formed by the loss of CO (28 mass units) from m/z 207 whereas m/z 125 was assigned to a chlorobenzyl cation. Based on the mode of fragmentation of drug to m/z 220 and 207 and their abundances, these ions can be used for quantitative analysis through selective reaction monitoring (SRM).

Keywords

Date Rape, Extraction, Juices, Ketamine, Mass Spectrometry, MEPS.
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  • Extraction and Analysis of Ketamine (a Rave Drug) from Spiked Fruit Juices Using MEPS-MS for Forensic Purposes

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Authors

Sandeep Singh Sahota
Department of Forensic Science, Punjabi University, Patiala 147 002, India
Jaswinder Singh
Department of Pharmaceutical Sciences and Drugs Research, Punjabi University, Patiala 147 002, India
Gulsan Bansal
Department of Forensic Science, Punjabi University, Patiala 147 002, India
Rakesh Kumar Garg
Department of Forensic Science, Punjabi University, Patiala 147 002, India

Abstract


Micro extraction packed sorbent (MEPS) containing C8 and SCX (strong cation exchange) is employed to extract ketamine, a rave drug from fruit juices. The eluant was detected by mass spectral analysis wherein the drug was detected as a parent as well as some prominent fragment ions. The resultant MEPS-MS method proved very efficient and rapid. The mass spectrum of the eluant showed the parent ion peak (MH+) of ketamine at m/z 238 along with (MH2+) peak (30% of MH+) due to chlorine atom in the drug molecule. The daughter ions at m/z 220 and 207 were possible to be formed from the MH+ by loss of water and methylamine molecule respectively. Another daughter ion at m/z 179 was proposed to be formed by the loss of CO (28 mass units) from m/z 207 whereas m/z 125 was assigned to a chlorobenzyl cation. Based on the mode of fragmentation of drug to m/z 220 and 207 and their abundances, these ions can be used for quantitative analysis through selective reaction monitoring (SRM).

Keywords


Date Rape, Extraction, Juices, Ketamine, Mass Spectrometry, MEPS.

References





DOI: https://doi.org/10.18520/cs%2Fv110%2Fi6%2F1059-1062