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Valproate Causing Recurrent Acute Pancreatitis


Affiliations
1 Dept. of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
2 Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
     

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Valproic acid is used either as monotherapy or in combination with other anticonvulsants for the treatment of simple, mixed and complex partial seizures, myoclonic seizure, generalised tonic- clonic seizure, acute manic episodes in bipolar disorder, and for prophylaxis of migraine headaches. The association of sodium valproate and pancreatitis is sometimes referred to as idiosyncratic as pancreatitis can develop after 1 week to 8 years of exposure to sodium valproate. We report a case of 39 year old male known case of seizure disorder presenting with recurrent episodes of epigatrium and right hypochondrium abdominal pain associated with vomiting over a period of 4 years. After excluding other causes of pancreatitis, a diagnosis of valproate induced necrotising pancreatitis was established.

Keywords

Valproic Acid, Pancreatitis.
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  • Pancreatitis associated with valproic acid: a review of the literature. Chapman SA, Wacksman GP, Patterson BD. Pharmacotherapy. 2001;21:1549– 1560.

  • Idiosyncratic adverse reactions to antiepileptic drugs. Zaccara G, Franciotta D, Perucca E. Epilepsia.2007;48:1223–1244.

  • Gerstner T, Büsing D, Bell N. et al. Valproic acidinduced pancreatitis:16 new cases and a review of the literature. J Gastroenterol. 2007;42(1):39–48.

  • Wilmink T, Frick WK. Drug induced pancreatitis. Drug safety 1996; 14: 406-423.

  • Pancreatitis associated with valproic acid therapy. Batalden PB, Van Dyne BJ, Cloyd J. Pediatrics.1979;64:520–522.

  • Pancreatitis due to valproic acid. Camfield PR, Bagnell P, Camfield CS, Tibbles JA. Lancet. 1979;1:1198–1199.

  • Hamad AE, Fawzi ME. Valproate associated acute pancreatitis. Neurosciences. 2000;5(3):156–8.

  • The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis. Sanfey H, Bulkley GB, Cameron JL. Ann Surg. 1984;200:405– 413.

  • Acute pancreatitis coincident with valproate use: a critical review. Pellock JM, Wilder BJ, Deaton R, Sommerville KW. Epilepsia. 2002;43:1421–1424.

  • Carnitine levels in valproic acid-treated psychiatric patients: a cross-sectional study. Moreno FA, Macey H, Schreiber B. J Clin Psychiatry. 2005;66:555–558.

  • The spectrum of valproic acid-associated pancreatitis. Werlin SL, Fish DL. Pediatrics. 2006;118:1660– 1663.


Abstract Views: 310

PDF Views: 3




  • Valproate Causing Recurrent Acute Pancreatitis

Abstract Views: 310  |  PDF Views: 3

Authors

K. Krishna
Dept. of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
A. Oswal
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
A. Vora
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
S. Jagtap
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
V. Chavan
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
N. Thangjam
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
S. Pawar
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India

Abstract


Valproic acid is used either as monotherapy or in combination with other anticonvulsants for the treatment of simple, mixed and complex partial seizures, myoclonic seizure, generalised tonic- clonic seizure, acute manic episodes in bipolar disorder, and for prophylaxis of migraine headaches. The association of sodium valproate and pancreatitis is sometimes referred to as idiosyncratic as pancreatitis can develop after 1 week to 8 years of exposure to sodium valproate. We report a case of 39 year old male known case of seizure disorder presenting with recurrent episodes of epigatrium and right hypochondrium abdominal pain associated with vomiting over a period of 4 years. After excluding other causes of pancreatitis, a diagnosis of valproate induced necrotising pancreatitis was established.

Keywords


Valproic Acid, Pancreatitis.

References