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Valproate Causing Recurrent Acute Pancreatitis


Affiliations
1 Dept. of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
2 Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
     

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Valproic acid is used either as monotherapy or in combination with other anticonvulsants for the treatment of simple, mixed and complex partial seizures, myoclonic seizure, generalised tonic- clonic seizure, acute manic episodes in bipolar disorder, and for prophylaxis of migraine headaches. The association of sodium valproate and pancreatitis is sometimes referred to as idiosyncratic as pancreatitis can develop after 1 week to 8 years of exposure to sodium valproate. We report a case of 39 year old male known case of seizure disorder presenting with recurrent episodes of epigatrium and right hypochondrium abdominal pain associated with vomiting over a period of 4 years. After excluding other causes of pancreatitis, a diagnosis of valproate induced necrotising pancreatitis was established.

Keywords

Valproic Acid, Pancreatitis.
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  • Valproate Causing Recurrent Acute Pancreatitis

Abstract Views: 304  |  PDF Views: 3

Authors

K. Krishna
Dept. of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
A. Oswal
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
A. Vora
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
S. Jagtap
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
V. Chavan
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
N. Thangjam
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India
S. Pawar
Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India

Abstract


Valproic acid is used either as monotherapy or in combination with other anticonvulsants for the treatment of simple, mixed and complex partial seizures, myoclonic seizure, generalised tonic- clonic seizure, acute manic episodes in bipolar disorder, and for prophylaxis of migraine headaches. The association of sodium valproate and pancreatitis is sometimes referred to as idiosyncratic as pancreatitis can develop after 1 week to 8 years of exposure to sodium valproate. We report a case of 39 year old male known case of seizure disorder presenting with recurrent episodes of epigatrium and right hypochondrium abdominal pain associated with vomiting over a period of 4 years. After excluding other causes of pancreatitis, a diagnosis of valproate induced necrotising pancreatitis was established.

Keywords


Valproic Acid, Pancreatitis.

References