International Journal of Medical Sciences

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Jatamansi:A Source against Lung and Colon Cancer Cells


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1 Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus Chatha, JAMMU (J&K), India
     

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In vitro assay for cytotoxic activity of Nardostachys jatamansi has been carried out against eight human cancer cell lines from six different tissues via 95 per cent methanolic and aqueous extract at the concentration of 100 μg/ml using Sulphorhodamine blue (SRB) assay. Results revealed that methanolic extract from the stem leaves of N. jatamansi showed highest in vitro cytotoxic effect against four human cancer cell lines (A-549, COLO-205, SW-620, NCI-H322) from lung and colon origin. Based on in vitro data, it is suggested that further in vivo studies as well as identification of effective components from methanolic extract and their exact mechanism of action could be useful in designing new anticancer therapeutic agents.

Keywords

Nardostachys jatamansi, In vitro Cytotoxic, Cancer Cells, SRB Assay.
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  • Jatamansi:A Source against Lung and Colon Cancer Cells

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Authors

Vikas Sharma
Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus Chatha, JAMMU (J&K), India

Abstract


In vitro assay for cytotoxic activity of Nardostachys jatamansi has been carried out against eight human cancer cell lines from six different tissues via 95 per cent methanolic and aqueous extract at the concentration of 100 μg/ml using Sulphorhodamine blue (SRB) assay. Results revealed that methanolic extract from the stem leaves of N. jatamansi showed highest in vitro cytotoxic effect against four human cancer cell lines (A-549, COLO-205, SW-620, NCI-H322) from lung and colon origin. Based on in vitro data, it is suggested that further in vivo studies as well as identification of effective components from methanolic extract and their exact mechanism of action could be useful in designing new anticancer therapeutic agents.

Keywords


Nardostachys jatamansi, In vitro Cytotoxic, Cancer Cells, SRB Assay.

References