Journal of Endocrinology and Reproduction

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Metablites of Melatonin:Formation and Properties of Methoxylated Kynuramines


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1 Institute of Zoology and Anthropology, University of Goettingen, Germany
     

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Melatonin, by virtue of its radical scavenging and electron-donating properties, can be oxidized by various enzymatic and non-enzymatic mechanisms. Apart form 6-hydroxymelatonin, cycle 3-hydroxymelatonin and some unidentified substances, a major product, AFMK (=N1-acetyl-N2-formyl-5 mehoxykynuramine), is formed by pyrrole-ring cleavage.
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  • Metablites of Melatonin:Formation and Properties of Methoxylated Kynuramines

Abstract Views: 281  |  PDF Views: 0

Authors

R. Hardeland
Institute of Zoology and Anthropology, University of Goettingen, Germany
A. R. Ressmeyer
Institute of Zoology and Anthropology, University of Goettingen, Germany
V. Zelosko
Institute of Zoology and Anthropology, University of Goettingen, Germany
S. Burkhardt
Institute of Zoology and Anthropology, University of Goettingen, Germany
B. Poeggeler
Institute of Zoology and Anthropology, University of Goettingen, Germany

Abstract


Melatonin, by virtue of its radical scavenging and electron-donating properties, can be oxidized by various enzymatic and non-enzymatic mechanisms. Apart form 6-hydroxymelatonin, cycle 3-hydroxymelatonin and some unidentified substances, a major product, AFMK (=N1-acetyl-N2-formyl-5 mehoxykynuramine), is formed by pyrrole-ring cleavage.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F98697