Journal of Endocrinology and Reproduction

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Adverse Effect of Diclofenac on Testicular Steroidogenesis


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1 Department of Zoology, Bharathiar University, Coimbatore-641046, India
     

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The effects of diclofenac sodium on the activities of the steroidogenic enzymes 3β-Phydroxy steroid dehydrogenase and 17β-Phydroxy steroid dehydrogenase as well as testosterone hormone titres were studied in albino rats, at a dosage of 300μg/kg. body weight for short, mid and long duration treatments. The effect of withdrawal of the drug for a month and supplementation with vitamin E were also studied.
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  • Adverse Effect of Diclofenac on Testicular Steroidogenesis

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Authors

K. Sakthishree
Department of Zoology, Bharathiar University, Coimbatore-641046, India
M. Selvaraj
Department of Zoology, Bharathiar University, Coimbatore-641046, India
G. Vanithakumari
Department of Zoology, Bharathiar University, Coimbatore-641046, India

Abstract


The effects of diclofenac sodium on the activities of the steroidogenic enzymes 3β-Phydroxy steroid dehydrogenase and 17β-Phydroxy steroid dehydrogenase as well as testosterone hormone titres were studied in albino rats, at a dosage of 300μg/kg. body weight for short, mid and long duration treatments. The effect of withdrawal of the drug for a month and supplementation with vitamin E were also studied.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F99240