Journal of Pharmaceutical Research

The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader).

If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

Fullscreen Fullscreen Off


Lafutidine (LTD) is used as antiulcer and mucosal protective. A new simple, economical and rapid UVSpectrophotometric first order derivative method using 'Area Under Curve' (AUC) technique has been developed for the quantitative determination of LTD in bulk and tablets. Methanol (20% v/v) was used as a solvent. Zero order spectrum of LTD was derivatised into first order using UV-probe software of the UVVis Spectrophotometer and the AUC was determined between the two selected wavelength 276.80 nm to 306.00 nm. LTD followed linearity in the concentration range of 10 - 80 μg/mL with r2 > 0.99. The quantity of drug estimated by this method was in good accord with label claimed. This method was found to be accurate, precise and ruggedness as shown by low values of % RSD.

Keywords

Lafutidine, UV-Spectrophotometry, First Order Derivative, Area under Curve.
User
Notifications
Font Size