Journal of Pharmaceutical Research

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Employment of Combined Carriers for Dissolution Enhancement of Celecoxib


Affiliations
1 DCRM Pharmacy College, Inkollu, Prakasam Dt., Pin : 523 167, Andhra Pradesh, India
2 Vishwa Bharathi College of Pharmaceuticals, Perecherla, Guntur Dt., Pin : 522 009, A.P., India
3 Chilukuri Balaji Pharmacy College, Aziz Nagar, Moinabad, Hyderabad, Pin 500 075, A.P., India
 

Solid Dispersions of celecoxib (C) with water soluble polymers polyvinylpyrrolidine (PVP), polyethylene glycol (PEG), hydroxylpropylmethylcellulose (HPMC) and a superdisintegrant namely microcrystalline cellulose (MCC) were prepared by common solvent and solvent evaporation methods employing methanol as solvent. Solid Dispersions prepared were evaluated for dissolution rate and dissolution efficiency in comparison to the corresponding pure drug. Solid dispersions of celecoxib showed a marked enhancement in dissolution rate and dissolution efficiency. Solid dispersions of C:HPMC:MCC at 2:2:10 ratio showed 7.71 fold increase in the dissolution rate of celecoxib. Solid dispersions in combined carriers gave much higher rates of dissolution than MCC alone. MCC alone or in combination with hydrophilic polymers could be used to enhance the dissolution rate of poorly soluble drug celecoxib.

Keywords

Celecoxib, Solid Dispersions, Dissolution Rate, Solubility, Superdisintegrant, Hydrophilic Polymer.
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  • Employment of Combined Carriers for Dissolution Enhancement of Celecoxib

Abstract Views: 239  |  PDF Views: 94

Authors

M. V. Nagabhushanam
DCRM Pharmacy College, Inkollu, Prakasam Dt., Pin : 523 167, Andhra Pradesh, India
Ch. V. Prasada Rao
Vishwa Bharathi College of Pharmaceuticals, Perecherla, Guntur Dt., Pin : 522 009, A.P., India
Ch. Prabhakar
Chilukuri Balaji Pharmacy College, Aziz Nagar, Moinabad, Hyderabad, Pin 500 075, A.P., India

Abstract


Solid Dispersions of celecoxib (C) with water soluble polymers polyvinylpyrrolidine (PVP), polyethylene glycol (PEG), hydroxylpropylmethylcellulose (HPMC) and a superdisintegrant namely microcrystalline cellulose (MCC) were prepared by common solvent and solvent evaporation methods employing methanol as solvent. Solid Dispersions prepared were evaluated for dissolution rate and dissolution efficiency in comparison to the corresponding pure drug. Solid dispersions of celecoxib showed a marked enhancement in dissolution rate and dissolution efficiency. Solid dispersions of C:HPMC:MCC at 2:2:10 ratio showed 7.71 fold increase in the dissolution rate of celecoxib. Solid dispersions in combined carriers gave much higher rates of dissolution than MCC alone. MCC alone or in combination with hydrophilic polymers could be used to enhance the dissolution rate of poorly soluble drug celecoxib.

Keywords


Celecoxib, Solid Dispersions, Dissolution Rate, Solubility, Superdisintegrant, Hydrophilic Polymer.