Journal of Pharmaceutical Research

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Solid Dispersions of celecoxib (C) with water soluble polymers polyvinylpyrrolidine (PVP), polyethylene glycol (PEG), hydroxylpropylmethylcellulose (HPMC) and a superdisintegrant namely microcrystalline cellulose (MCC) were prepared by common solvent and solvent evaporation methods employing methanol as solvent. Solid Dispersions prepared were evaluated for dissolution rate and dissolution efficiency in comparison to the corresponding pure drug. Solid dispersions of celecoxib showed a marked enhancement in dissolution rate and dissolution efficiency. Solid dispersions of C:HPMC:MCC at 2:2:10 ratio showed 7.71 fold increase in the dissolution rate of celecoxib. Solid dispersions in combined carriers gave much higher rates of dissolution than MCC alone. MCC alone or in combination with hydrophilic polymers could be used to enhance the dissolution rate of poorly soluble drug celecoxib.

Keywords

Celecoxib, Solid Dispersions, Dissolution Rate, Solubility, Superdisintegrant, Hydrophilic Polymer.
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