Research Journal of Pharmaceutical Dosage Form and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Efficient and Viable Synthesis Development for Tiaprofenic Acid in Pharmaceutical Industries


Affiliations
1 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, India
2 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, India
3 Department of Chemistry, Maharajah’s College (Aided & Autonomous), Vizianagaram-535002, AP, India
4 Tyche Industries Limited, 11-15-28, Siris Complex, Doctors Colony, L B Nagar, Hyderabad-500074, India
     

   Subscribe/Renew Journal


An industrially efficient method was developed to synthesize of tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1) which is a very important pharmaceutical compound having anti-inflammatory and analgesic activity. Sodium salt of propionitrile is reacted with 5-benzoyl-2- bromothiophene (4) to yield nitrile crude (5) and further hydrolysis to give tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1).

Keywords

Sodamide, Propionitrile, Anti-Inflammatory, Tiaprofenic Acid, NSAID.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 297

PDF Views: 0




  • Efficient and Viable Synthesis Development for Tiaprofenic Acid in Pharmaceutical Industries

Abstract Views: 297  |  PDF Views: 0

Authors

K. Raghubabu
Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, India
N. Mohan
Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, India
B. Kalyanaramu
Department of Chemistry, Maharajah’s College (Aided & Autonomous), Vizianagaram-535002, AP, India
C. Ramadas
Tyche Industries Limited, 11-15-28, Siris Complex, Doctors Colony, L B Nagar, Hyderabad-500074, India
M. Narayanarao
Tyche Industries Limited, 11-15-28, Siris Complex, Doctors Colony, L B Nagar, Hyderabad-500074, India

Abstract


An industrially efficient method was developed to synthesize of tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1) which is a very important pharmaceutical compound having anti-inflammatory and analgesic activity. Sodium salt of propionitrile is reacted with 5-benzoyl-2- bromothiophene (4) to yield nitrile crude (5) and further hydrolysis to give tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1).

Keywords


Sodamide, Propionitrile, Anti-Inflammatory, Tiaprofenic Acid, NSAID.