Research Journal of Pharmaceutical Dosage Form and Technology

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Efficient and Viable Synthesis Development for Tiaprofenic Acid in Pharmaceutical Industries


Affiliations
1 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, India
2 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, India
3 Department of Chemistry, Maharajah’s College (Aided & Autonomous), Vizianagaram-535002, AP, India
4 Tyche Industries Limited, 11-15-28, Siris Complex, Doctors Colony, L B Nagar, Hyderabad-500074, India
     

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An industrially efficient method was developed to synthesize of tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1) which is a very important pharmaceutical compound having anti-inflammatory and analgesic activity. Sodium salt of propionitrile is reacted with 5-benzoyl-2- bromothiophene (4) to yield nitrile crude (5) and further hydrolysis to give tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1).

Keywords

Sodamide, Propionitrile, Anti-Inflammatory, Tiaprofenic Acid, NSAID.
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  • Efficient and Viable Synthesis Development for Tiaprofenic Acid in Pharmaceutical Industries

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Authors

K. Raghubabu
Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, India
N. Mohan
Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, India
B. Kalyanaramu
Department of Chemistry, Maharajah’s College (Aided & Autonomous), Vizianagaram-535002, AP, India
C. Ramadas
Tyche Industries Limited, 11-15-28, Siris Complex, Doctors Colony, L B Nagar, Hyderabad-500074, India
M. Narayanarao
Tyche Industries Limited, 11-15-28, Siris Complex, Doctors Colony, L B Nagar, Hyderabad-500074, India

Abstract


An industrially efficient method was developed to synthesize of tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1) which is a very important pharmaceutical compound having anti-inflammatory and analgesic activity. Sodium salt of propionitrile is reacted with 5-benzoyl-2- bromothiophene (4) to yield nitrile crude (5) and further hydrolysis to give tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1).

Keywords


Sodamide, Propionitrile, Anti-Inflammatory, Tiaprofenic Acid, NSAID.