New Simple, Sensitive and Economical UV Spectrophotometric Method for Estimation of Risperidone in Tablet Dosage Form and its Peroxide Degradation Kinetic.

New simple, economic, sensitive, accurate UV Spectrophotometric method has been developed for determination of Risperidone in tablet dosage form. Method of estimation for Risperidone based on two wavelengths viz. 238 nm and 276 nm, by solvent mixture of 0.1N HCl: Methanol in the proportion of 30:70. Risperidone shows linearity and obeys Beer’s law in the concentration range of 3 to 27μg ml-1 at both wavelengths. The results of analysis are validated by statistical evaluation and recovery studies, and method can be extended to the analysis of Risperidone in tablet formulations. A kinetic investigation of the peroxide hydrolysis of Risperidone was carried out in 1% and 3% Hydrogen peroxide solution. The rate constant for degradation were estimated as per pseudo-first order kinetic.