Research Journal of Pharmaceutical Dosage Form and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Glimepiride Micro Balloons:A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System


Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
     

   Subscribe/Renew Journal


Present research work was aimed to formulate and evaluate the gastro-retentive floating microballoons of glimepiride using hydrophilic polymers hydroxypropyl methylcellulose and Eudragit RS100 by emulsion solvent evaporation technique. The developed gastro retentive floating drug delivery system was evaluated for various parameters like micromeritic properties, buoyancy, in-vitro drug release, etc. It was observed that the drug delivery systems of glimepiride has shown excellent physicochemical properties, stability and controlled drug release pattern, by improving the bioavailability of the drug and also by managing the complicacy of the diabetes in a better manner.

Keywords

Floating Microspheres, Glimepiride, in-vitro Drug Release, Solubility.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Ritesh Kumar, Surbhi Kamboj, Amrish Chandra, Pawan Kumar Gautam, Vijay Kumar Sharma: Microballoons: An Advance Avenue for Gastroretentive Drug Delivery System- A Review; UK Journal of Pharmaceutical and Biosciences, 2016;4(4), 29-40.

  • Mayur D. Chaudhary, Raju O Sonawane, Laxmikant Zawar, Sasmita Nayak, and Sanjay B Bari: Solubility and Dissolution Enhancement of Poorly water soluble Glimepiride by using Solid dispersion Technique; International Journal of Pharmacy and Pharmaceutical Sciences, 2012; 4(5) 534-539.

  • Manas Tripathi, P. R. Radhika, and T. Sivakumar: Formulation and Evaluation of Glipizide Hollow Micro balloons for Floating Drug Delivery; Bulletin of Pharmaceutical Research, 2011; 1(1):67-74.

  • V. Ganesan, V.S.V.S.P. Krishna Kanth: Preparation and In-vitro Evaluation of Micro balloon Drug Delivery System of Telmisartan; International Journal of Pharmaceutical Sciences and Drug Research, 2013; 5(4): 141-145.

  • Manish Dubey, Prashant Kesharwani, Amit Tiwari, Roshni Chandel, K. Raja, T. Sivakumar : Formulation and Evaluation of Floating Microsphere Containing Anti Diabetic Drug; International Journal of Pharmaceutical and Chemical Sciences, 2012 ;1(3): 1387-1396.


Abstract Views: 263

PDF Views: 0




  • Glimepiride Micro Balloons:A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Abstract Views: 263  |  PDF Views: 0

Authors

Rutuja R. Shah
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
Rutuja S. Shah
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
Rohan R. Vakhariya
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India

Abstract


Present research work was aimed to formulate and evaluate the gastro-retentive floating microballoons of glimepiride using hydrophilic polymers hydroxypropyl methylcellulose and Eudragit RS100 by emulsion solvent evaporation technique. The developed gastro retentive floating drug delivery system was evaluated for various parameters like micromeritic properties, buoyancy, in-vitro drug release, etc. It was observed that the drug delivery systems of glimepiride has shown excellent physicochemical properties, stability and controlled drug release pattern, by improving the bioavailability of the drug and also by managing the complicacy of the diabetes in a better manner.

Keywords


Floating Microspheres, Glimepiride, in-vitro Drug Release, Solubility.

References