Research Journal of Pharmaceutical Dosage Form and Technology

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Glimepiride Micro Balloons:A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System


Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
     

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Present research work was aimed to formulate and evaluate the gastro-retentive floating microballoons of glimepiride using hydrophilic polymers hydroxypropyl methylcellulose and Eudragit RS100 by emulsion solvent evaporation technique. The developed gastro retentive floating drug delivery system was evaluated for various parameters like micromeritic properties, buoyancy, in-vitro drug release, etc. It was observed that the drug delivery systems of glimepiride has shown excellent physicochemical properties, stability and controlled drug release pattern, by improving the bioavailability of the drug and also by managing the complicacy of the diabetes in a better manner.

Keywords

Floating Microspheres, Glimepiride, in-vitro Drug Release, Solubility.
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  • Glimepiride Micro Balloons:A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Abstract Views: 264  |  PDF Views: 0

Authors

Rutuja R. Shah
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
Rutuja S. Shah
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
Rohan R. Vakhariya
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India

Abstract


Present research work was aimed to formulate and evaluate the gastro-retentive floating microballoons of glimepiride using hydrophilic polymers hydroxypropyl methylcellulose and Eudragit RS100 by emulsion solvent evaporation technique. The developed gastro retentive floating drug delivery system was evaluated for various parameters like micromeritic properties, buoyancy, in-vitro drug release, etc. It was observed that the drug delivery systems of glimepiride has shown excellent physicochemical properties, stability and controlled drug release pattern, by improving the bioavailability of the drug and also by managing the complicacy of the diabetes in a better manner.

Keywords


Floating Microspheres, Glimepiride, in-vitro Drug Release, Solubility.

References