![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_open_medium.gif)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_restricted_medium.gif)
Screening and Optimization of an Aqueous Based Natural Polymer
Subscribe/Renew Journal
The recent study includes the extraction and characterization of tamarind gum, Tamarindus indica from Tamarind seeds which is used in the pharmaceutical, textile and food industries as a mucoadhesive polymer. It belongs to a Leguminosae family. Aim of the present work is to establish that the Tamarind gum use as a natural polymer. Water based extraction procedure was used to extract polysaccharide from tamarind seed. For characterization of extracted gum, different Pharmacopoeial methods like micromeritic properties, solubility, DSC, FTIR, organoleptic properties and pH is studied. The extracted gum is insoluble in organic solvents like ethanol, acetone, methanol, ether etc as well as cold water which formed the basis of separation and procurement of the gum. It is only soluble in hot water. It yields a highly viscous colloidal solution at temperature above 850°C. It is also found that extracted tamarind gum has good flow properties and pH is 6.6. The tamarind seed polysaccharide is a pH sensitive polymer which being activated only in basic pH. It can be concluded from the whole study and their evaluation that tamarind seed polysaccharide can be an important pharmaceutical excipient which can be used in solid dosage form without any irritation. Obtained results also showed that extracted seed polysaccharide may be used as natural gelling agents in different pharmaceutical formulations. Future works will focus on the quantitative analysis, biological activity and possible use of Tamarind Seed Polysaccharide as a drug delivery system.
Keywords
Tamarindus indica, Natural Polysaccharide, Pharmacpoeial Method, Extraction, Characterization, Pharmaceutical Excipient, Aqueous Based Natural Polymer.
Subscription
Login to verify subscription
User
Font Size
Information
- Gwen MJ, Joseph RR, Rhodes CT. Modern Pharmaceutics, Marcel Dekker, New York. 1996.
- Malviya R, Srivastava P, Kulkarni GT. Application of mucilages in drug delivery-A review. Advances in Biological Research. 2011; 5: 01-07.
- Langer RS, Peppas NA. Present and future application of biomaterials in controlled drug delivery systems. Biomaterials.1 981; 2(4): 201-214.
- Roohullah et al. Sustained Release Carbamezapine Matrix Tablets Prepared by Solvent-Evaporation Technique Using Different Polymers. Middle-East Journal of Scientific Research. 2013; 15: 1368-1374.
- Rao PS and Srivastav HC. Tamarind in Industrial Gum, Ed: Academic Press, New York. 1973.
- Glicksman M. Tamarind seed gum, In: M. Glicksman (Ed.), Food Hydrocolloids. CRC Press Inc., Boca Raton, Florida, USA, 1996; 3: 191‑202.
- Ghelardi E et al. Effect of a novel mucoadhesive polysaccharide obtained from tamarind seeds on the intraocular penetration of gentamicin and ofloxacin in rabbits. Journal of Antimicrobial Chemotherapy. 2000; 46(5): 831-840.
- Navneet.S., Pooja. M. Development and Evaluation of Compression Coated Colon Targeted Tablets of Aceclofenac by Using Natural Polymers. Asian Journal of Pharmaceutical and Clinical Research. 2011; 4(4): 93-98.
- Malviya R et al. Formulation, Evaluation and Comparison of Sustained Release Matrix Tablets of Diclofenac Sodium Using tamarind Gum as Release Modifier. Asian Journal of Pharmaceutical and Clinical Research. 2010; 3(3): 238-41.
- Malviya R. Extraction and characterization of selected mucilage as a pharmaceutical excipients. Polymers in Medicine. 2011; 3: 39-44.
- Sing R, Malviya R and Sharma PK. Extraction and characterization of Tamarind Seed Polysaccharide as a Pharmaceutical Excipients. Pharmacognosy Journal. 2011; 3(20): 17-19
- Katiyar N, Malviya R and Sharma PK. Pharmaceutical Applications and Formulation Based Patents of Tamarindus indica Seed Polysaccharide and Their Modified Derivatives. Advances in Biological Research. 2014; 8(6): 274-281.
- Kokate CK. Practical Pharmacognosy. Vallabh Prakashan, New Delhi. 1991.
- Srivastava P et al. Preparation and Evaluation of Disintegrating Properties of Cucurbita maxima Pulp Powder. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 2(1): 395-399.
- Bansal S et al. Evaluation of Various Natural Gums as Release Modifiers in Tablet Formulations. Pharmacognosy Journal. 2010; 2(13): 525-529.
![](https://i-scholar.in/public/site/images/abstractview.png)
Abstract Views: 541
![](https://i-scholar.in/public/site/images/pdfview.png)
PDF Views: 1