Research Journal of Pharmaceutical Dosage Form and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Development and Characterization of Lipospheres Containing RepaglinideDevelopment and Characterization of Lipospheres Containing Repaglinide


Affiliations
1 Department of Pharmaceutics, M.M.U College of Pharmacy, Ramanagaram., India
     

   Subscribe/Renew Journal


Lipospheres formulation is an aqueous micro dispersion of solid water insoluble spherical micro the lipospheres are prepared of solid hydrophobic triglycerides with a monolayer of phospholipids embedded on the shell of the particle. Repaglinide is a water insoluble ant diabetic drug which belongs to the class of medications known as meglitinides. An attempt was made to develop and characterized the lipospheres in order to enhance the bioavailability of a highly permeable and a poorly soluble anti-diabetic drug by using different concentrations of bees wax, stearic acid, cetyl alcohol, tween 80 and phospholipids coat such as soybean phosphotidylcholine. The lipospheres were prepared by solvent evaporation technique and characterized for particle size, scanning electron microscopy, % entrapment efficiency, % yield, % drug content, in vitro drug release and stability study. All the formulation gave the satisfactory result in terms of particle size, entrapment efficiency and drug content. Lipospheres were substantially stable after 3 months storage at 2–8°C.

Keywords

Repaglinide, Lipospheres, Solvent evaporation technique, stability studies.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Luxenhofer R, Schulz A, Roques C, Li S, Bronich TK, Batrakova EV. Doubly amphiphilic poly (2-oxazoline) as high-capacity delivery systems for hydrophobic drugs. Biomaterials 2010;31(18):4972-79.

  • Fricker G, Kromp T, Wendel A, Blume A, Zirkel J, Rebmann H. Phospholipids and lipid-based formulations in oral drug delivery. Pharm Res 2010;27(8):1469-86.

  • Dudala TB, Yalavarthi PR, Pasupati VK. A Perspective overview on lipospheres. Int J Pharma Investig. 2014;4(4):149-55.

  • Inoue K. Ex vivo anti-platelet effects of isocarbacyclin methyl ester incorporated in lipid microspheres in rabbits. Arzneim Forsch Drug Res 1995;45(9):980-84.

  • Muller RH. Solid lipid nanoparticles (SLN) as potential carrier for human use interaction with human granulocytes. J Control Rel 1997; 47: 261-69.

  • Jang JH, Shea LD. Intramuscular delivery of DNA releasing microspheres: microsphere properties and transgene expression. J Control Release 2006;112(1):120-28.

  • Chavda HV, Patel CN, Anand IS. Biopharmaceutics classification system. Sys Rev Pharm 2010;1(1):62-9.

  • Repaglinide: [Internet]. Cited Feb 2019 available from http: //pdf.hres.ca/dpd _pm.PDF.

  • Attama AA, Okafor CE, Builders PF, Okorie O. Formulation and in vitro evaluation of a PEGylated microscopic lipospheres delivery system for ceftriaxone sodium. Drug Deliv 2009; 16(8): 448-57.

  • Kalyankar TM, Kakde RB. Reverse phase liquid chromatographic method for simultaneous determination of metformin and repaglinide in pharmaceutical preparations. Res J Pharma Dosage form Tech 2011;3(5):233-37.

  • Kishor K, Gopalkrishna SV, Subbareddy GV. Optimization of repaglinide control release floating tablet. Res J Pharm Tech 2021;14(1):109-114.

  • Hyma ponnaganti, Abullu K. Enhanced dissolution of repaglinide: SMEDDS formulation and in vitro evaluation. Res J Pharm Tech 2014;7(11):1246-52.

  • Chime SA, Kenechukwu FC, Onunkwo, Anthony A, Jhon D. Recent advances in lipospheres drug delivery system. J Pharm Res 2015;5(3):1743-48.

  • Nasr M, Mansour S, Nahed D. Mortada, EL Shamy. Lipospheres as carriers for topical delivery of aceclofenac: Preparation, characterization and in vivo evaluation. Pharm Sci Tech 2008;9(1):154-62.

  • Saminathan C, Venkatesan P, Madhusudhan S. Selection of better method for the preparation of nanoparticles by applying anytic heirarchi process. Res J Pharm Tech 2019;12(11):5320-24.

  • Sahu M, Bhowmick M, Rathi J. Preformulation screening of repaglinide for transdermal anti diabetic therapy. J Drug Del Ther 2017;7(4):103-09.

  • Jagde R, Singhor R, Daharwal SJ. Compatability studies between gatifloxacin and pharmaceutical excipient through differential scanning calorimetry and infra red spectroscopy. Res J Pharm Dosage Form Tech 2010;2(1):103-6.

  • Shivshare UD, Chopkr PT, Mathur VB, Ramteke VI. Effect of formulation variables on pharmacotechnical properties of carvedilol self emulsifying drug delivery system. Res J Pharma Dosage Form Tech 2009;1(3):275-79.

  • Satheesh babu N, Prabakaran L, Gowthamarajan K. Ofloxacin loaded lipid colloidal carrier(lipospheres)for treatment of bacterial infections. Res J Pharm Tech 2011;4(8):1234-36.

  • Talokar SS, Vakhariya RR. Formulation and evaluation of lomefloxacin microspheres. Res J Pharm Dosage Form Tech 2017;9(1):1-5.

  • Gavini V, Murthy MS, Kumar K. Formulation and in vitro evaluation of nanoparticulate drug delivery system loaded with 5- flourouracil. Res J Pharm Dosage Form Tech 2014;6(4):243-48.

  • Preeti K, Priyanka M. Formulation and evaluation of vinopectine loaded lipospheres. Int J Pharm Pharma Sci 2012;4(3):470-73.

  • Ganesan V, Allimalarkodi S. Formulation and in vitro evaluation cefixime lipospheres. World J Pharma Res 2015;4(10);1266-80.

  • Stability studies:[Internet].Cited March 2020. Available from https://shodhganga .inflibnet.ac.in/bitstream/10603/18214/14/14_chapter%2007.pdf.


Abstract Views: 139

PDF Views: 0




  • Development and Characterization of Lipospheres Containing RepaglinideDevelopment and Characterization of Lipospheres Containing Repaglinide

Abstract Views: 139  |  PDF Views: 0

Authors

Misbah Nikhath
Department of Pharmaceutics, M.M.U College of Pharmacy, Ramanagaram., India
Vazir Ashfaq Ahmed
Department of Pharmaceutics, M.M.U College of Pharmacy, Ramanagaram., India

Abstract


Lipospheres formulation is an aqueous micro dispersion of solid water insoluble spherical micro the lipospheres are prepared of solid hydrophobic triglycerides with a monolayer of phospholipids embedded on the shell of the particle. Repaglinide is a water insoluble ant diabetic drug which belongs to the class of medications known as meglitinides. An attempt was made to develop and characterized the lipospheres in order to enhance the bioavailability of a highly permeable and a poorly soluble anti-diabetic drug by using different concentrations of bees wax, stearic acid, cetyl alcohol, tween 80 and phospholipids coat such as soybean phosphotidylcholine. The lipospheres were prepared by solvent evaporation technique and characterized for particle size, scanning electron microscopy, % entrapment efficiency, % yield, % drug content, in vitro drug release and stability study. All the formulation gave the satisfactory result in terms of particle size, entrapment efficiency and drug content. Lipospheres were substantially stable after 3 months storage at 2–8°C.

Keywords


Repaglinide, Lipospheres, Solvent evaporation technique, stability studies.

References