Research Journal of Pharmaceutical Dosage Form and Technology

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Development and Characterization of Lipospheres Containing RepaglinideDevelopment and Characterization of Lipospheres Containing Repaglinide


Affiliations
1 Department of Pharmaceutics, M.M.U College of Pharmacy, Ramanagaram., India
     

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Lipospheres formulation is an aqueous micro dispersion of solid water insoluble spherical micro the lipospheres are prepared of solid hydrophobic triglycerides with a monolayer of phospholipids embedded on the shell of the particle. Repaglinide is a water insoluble ant diabetic drug which belongs to the class of medications known as meglitinides. An attempt was made to develop and characterized the lipospheres in order to enhance the bioavailability of a highly permeable and a poorly soluble anti-diabetic drug by using different concentrations of bees wax, stearic acid, cetyl alcohol, tween 80 and phospholipids coat such as soybean phosphotidylcholine. The lipospheres were prepared by solvent evaporation technique and characterized for particle size, scanning electron microscopy, % entrapment efficiency, % yield, % drug content, in vitro drug release and stability study. All the formulation gave the satisfactory result in terms of particle size, entrapment efficiency and drug content. Lipospheres were substantially stable after 3 months storage at 2–8°C.

Keywords

Repaglinide, Lipospheres, Solvent evaporation technique, stability studies.
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  • Development and Characterization of Lipospheres Containing RepaglinideDevelopment and Characterization of Lipospheres Containing Repaglinide

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Authors

Misbah Nikhath
Department of Pharmaceutics, M.M.U College of Pharmacy, Ramanagaram., India
Vazir Ashfaq Ahmed
Department of Pharmaceutics, M.M.U College of Pharmacy, Ramanagaram., India

Abstract


Lipospheres formulation is an aqueous micro dispersion of solid water insoluble spherical micro the lipospheres are prepared of solid hydrophobic triglycerides with a monolayer of phospholipids embedded on the shell of the particle. Repaglinide is a water insoluble ant diabetic drug which belongs to the class of medications known as meglitinides. An attempt was made to develop and characterized the lipospheres in order to enhance the bioavailability of a highly permeable and a poorly soluble anti-diabetic drug by using different concentrations of bees wax, stearic acid, cetyl alcohol, tween 80 and phospholipids coat such as soybean phosphotidylcholine. The lipospheres were prepared by solvent evaporation technique and characterized for particle size, scanning electron microscopy, % entrapment efficiency, % yield, % drug content, in vitro drug release and stability study. All the formulation gave the satisfactory result in terms of particle size, entrapment efficiency and drug content. Lipospheres were substantially stable after 3 months storage at 2–8°C.

Keywords


Repaglinide, Lipospheres, Solvent evaporation technique, stability studies.

References