Research Journal of Pharmacognosy and Phytochemistry

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In-vitro Screening of Ficus racemosa for Anticancer Activity


Affiliations
1 JJT University, Vidyanagari, Jhunjhunu – Churu Road, Dist: Jhunjhunu, Rajasthan – 333001, India
2 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi – 370460, Dist: Kutch, Gujarat, India
3 Shree B.M Shah College of Pharmaceutical Education and Research, Modasa - 383315, Dist: Sabarkantha, Gujarat, India
     

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Ficus racemosa is a moderate sized avenue tree found throughout India. It is popular in indigenous system of medicine like Ayurveda, Siddha, Unani and Homoeopathy. Aim of the present study was undertaken with an objective to find out the anticancer activity of Ficus racemosa plant extracts using standard in-vitro MTT bioassay against various cancer cell lines (HL-60, HepG2, NCI-H23 and HEK-293T). With use of MTT dye, % cell viability and % inhibition of the hit compounds was evaluated within respective wavelengths prior with standard compounds. Data obtained from MTT bioassay screening revealed that methanolic extract of Ficus racemosa shown cytotoxic activity against HL-60 and HepG2 cell line with profound IC50 values and shown negligible toxicity against normal cell line (HEK- 293T).

Keywords

Ficus racemosa Linn., MTT Bioassay, Anticancer Activity.
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  • In-vitro Screening of Ficus racemosa for Anticancer Activity

Abstract Views: 261  |  PDF Views: 0

Authors

Prakash S. Sukhramani
JJT University, Vidyanagari, Jhunjhunu – Churu Road, Dist: Jhunjhunu, Rajasthan – 333001, India
G. Vidyasagar
Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi – 370460, Dist: Kutch, Gujarat, India
Piyush M. Patel
Shree B.M Shah College of Pharmaceutical Education and Research, Modasa - 383315, Dist: Sabarkantha, Gujarat, India

Abstract


Ficus racemosa is a moderate sized avenue tree found throughout India. It is popular in indigenous system of medicine like Ayurveda, Siddha, Unani and Homoeopathy. Aim of the present study was undertaken with an objective to find out the anticancer activity of Ficus racemosa plant extracts using standard in-vitro MTT bioassay against various cancer cell lines (HL-60, HepG2, NCI-H23 and HEK-293T). With use of MTT dye, % cell viability and % inhibition of the hit compounds was evaluated within respective wavelengths prior with standard compounds. Data obtained from MTT bioassay screening revealed that methanolic extract of Ficus racemosa shown cytotoxic activity against HL-60 and HepG2 cell line with profound IC50 values and shown negligible toxicity against normal cell line (HEK- 293T).

Keywords


Ficus racemosa Linn., MTT Bioassay, Anticancer Activity.