Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Cardiotonic Activity of some Traditionally Used Medicinal Plants


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1 Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
     

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The present study was undertaken to evaluate the cardiotonic activity of the aqueous, methanolic and chloroform extracts of the ischolar_mains of Hemidesmus indicus and fruits of Terminalia bellirica, Terminalia chebula. The cardiotonic effect of aqueous, methanolic and chloroform extracts of the three plants was studied by using isolated frog heart perfusion technique (IFHP). Ringer solution without calcium was used as a vehicle for administration of aqueous, methanolic and chloroform extracts as test and digoxin as standard. A significant increase in the height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed and as compared to standard, test drug showed wide therapeutic index.

Keywords

Cardiotinic Activity, Frog Heart Perfusion Technique, Digoxin, Therapeutic Index,Hemidesmus Indicus, Terminalia Bellirica, Terminalia Chebula
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  • Tripathi KD. Cardiac glycosides and drugs for CCF, Essentials of medical pharmacology. 5 th ed. Medical Publishers; 2003, 457-467.

  • Barar FSK, Essentials of Pharmacotherapeutics, 1st edition, S.Chand Publications, 1985, 253-254

  • Satoskar RS, Bhandarkar SD, Rege NN. Handbook of pharmacology and pharmacotherapeutics. 16 th ed. Popular Prakashan; 1997, 352-355.

  • Arun, V; Liju, V; Reena, J; et al. 2007. Traditional Remedies of Kani Tribes of Kottoor Reserve Forest, Agasthyavanam, Thiruvananthapuram, Kerala. Indian Journal of Traditional Knowledge, 2007, Vol.6(4), 589-594.

  • Alam MI, Audpy B, Gomes A. Viper venom neutralization by Indian medicinal plants (Hemidesmus indicus and Pluchea indica). Phytothery Resonance, 1996; 10: 58-61.

  • Alam Badrul . Antioxidant,Antimicrobial and Toxicity studies of the Different Fractions of Fruits of Terminalia belerica Roxb. Global Journal of Pharmacology. 2011;5(1):07-17.

  • Kumudhavalli MV, Vyas Mohit and Jayakar B. Phytochemical and Pharmacological evalution of the plant fruit of Terminalia belerica Roxb, International Journal of Pharmacy and Life Sciences. 2010; 1(1):1-11.

  • Suguna L, Singh S, Sivakumar P, Sampath P, Chandrakasan G. Influence of Terminalia chebula on dermal wound healing in rats. Phyther Res. 2002; 16:227–231.

  • Dama G.Y.,Tare H.L.,Gore M.S.,Shende V.S.,Deore S.R., Khandagale S.T.,Kandekar A.E. Comparative Cardiotonic Activity Of Helicteres Isora With Digoxin On Isolated Frog Heart. International Journal of Preclinical Research,Vol 2 | Issue 2 | Jul –Dec 2011 |81-86.

  • Mohire N.C., Salunkhe V.R., Bhaise S.B., Yadev A.V. Cardiotonic activity of aqueous extract of heartwood of Pterocarpus marsupium. Indian Journal of Experimental Biology, Vol.45, June 2007, 532-537.

  • Kulkarni SK, Handbook of Experimental Pharmacology, 2nd Edition, Vallabh Prakashan, 9, 1993, 74-76.

  • Kale SR, Kale RR. Practical Pharmacology and toxicology, 6th edition, Nirali Prakashan, 2003, 27- 28.

  • Tare HL, Thube BB. Comparative cardiotonic activity of C.angustifolia with digoxin on perfused frog heart. IJPRD, 1(1), 2009, 1-14.

  • Rai P.T. et al., Evaluation of Cardiotonic activity of leaves of Vitex negundo linn, International Journal of Green Pharmacy, Oct.-Dec.-2009, 306-309.

  • Goyal Ramesh K., Practicals in Pharmacology, 6th edition, B.S.Shah Prakashan, 2006-2007, 107-108.

  • Patel Rashmika P., Patel Manish P. Cardiotonic activity of isolated cardiac glycoside from the fruits of Corchorus aestuans linn, International Research Journal of Pharmacy, 2012, 3(7), 239-242.


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  • Evaluation of Cardiotonic Activity of some Traditionally Used Medicinal Plants

Abstract Views: 468  |  PDF Views: 2

Authors

K. Sanjeev Kumar
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
V. Vijay Kumar
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
A. G. Prasanthi
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
L. K. Kanthal
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
P. Bhoja Raju
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
K. Satyavathi
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India

Abstract


The present study was undertaken to evaluate the cardiotonic activity of the aqueous, methanolic and chloroform extracts of the ischolar_mains of Hemidesmus indicus and fruits of Terminalia bellirica, Terminalia chebula. The cardiotonic effect of aqueous, methanolic and chloroform extracts of the three plants was studied by using isolated frog heart perfusion technique (IFHP). Ringer solution without calcium was used as a vehicle for administration of aqueous, methanolic and chloroform extracts as test and digoxin as standard. A significant increase in the height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed and as compared to standard, test drug showed wide therapeutic index.

Keywords


Cardiotinic Activity, Frog Heart Perfusion Technique, Digoxin, Therapeutic Index,Hemidesmus Indicus, Terminalia Bellirica, Terminalia Chebula

References